Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

Nature Reviews Nephrology 12, 426 (2016). doi:10.1038/nrneph.2016.54 Authors: Maria Edeling, Grace Ragi, Shizheng Huang, Hermann Pavenstädt & Katalin Susztak Kidney fibrosis is a common histological manifestation of functional decline in the kidney. Fibrosis is a reactive process that develops in response to excessive epithelial injury and inflammation, leading to myofibroblast activation and an accumulation of extracellular matrix. Here, we describe how three key developmental
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Review Source Type: research