Perioperative high inspired oxygen fraction therapy reduces surgical site infection with Pseudomonas aeruginosa in rats.

In this report, we designed a rat model for muscle surgery to compare the effectiveness of short-term perioperative treatments with high (FiO2 = 80%) versus a standard low (FiO2 = 30%) oxygen in reducing SSI with Pseudomonas aeruginosa-- one of the most prevalent Gram-negative pathogens, responsible for nosocomial SSIs. Our data demonstrate that 5-h perioperative treatment with 80% FiO2 is significantly more effective in reducing SSI with P. aeruginosa compared to 30% FiO2 treatment. We further show that while 80% and 30% FiO2 treatments do not affect neutrophil infiltration into P. aeruginosa-infected muscles, neutrophils in the 80% FiO2 treated and infected animal group are significantly more activated than neutrophils in the 30% FiO2 treated and infected animal group, suggesting that high oxygen perioperative treatment reduces SSI with P. aeruginosa by enhancing neutrophil activation in infected wounds.
PMID: 27302326 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - June 13, 2016 Category: Microbiology Authors: Kroin JS, Li J, Goldufsky JW, Gupta K, Moghtaderi M, Buvanendran A, Shafikhani SH Tags: J Med Microbiol Source Type: research