DNA damage in protective and adverse inflammatory responses: Friend of foe?

Publication date: Available online 15 June 2016 Source:Mechanisms of Ageing and Development Author(s): Tetiana Poliezhaieva, Maria Ermolaeva The impact of DNA damage-induced immune responses on aging and disease development is a topic of top scientific interest and debate. While abundant data links persistent genotoxic stress and associated inflammatory activity to organ decline and cancer development, evidence of pro-homeostatic effects of immune responses triggered by transient DNA damage gradually accumulates. Current review focuses on comparing systemic consequences of transient genotoxicity with effects of persistent DNA damage from the angle of associated immune activity. We discuss DNA damage as a potential DAMP (damage associated molecular pattern) which acts by alerting the organism of incoming grander damage and pre-conditions the body for damage tolerance and repair.
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research