Conformation of ryanodine receptor-2 gates store-operated calcium entry in rat pulmonary arterial myocytes

Conclusions
RyR2-gated Ca2+ store contributes to SOCE in PASMCs; however, store-depletion alone is insufficient but requires a specific RyR conformation modifiable by ryanodine binding to activate Ca2+ entry.

Source: Cardiovascular Research - June 14, 2016 Category: Cardiology Authors: Lin, A. H. Y., Sun, H., Paudel, O., Lin, M.-J., Sham, J. S. K. Tags: Vascular Biology Source Type: research