From acid reflux to allergies, we reveal what's causing YOUR persistent cough

Most persistent coughs are caused by gastric reflux, which makes the upper airways hypersensitive. But some can be caused by asthma, a side effect of medication, an infection - or even lung cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Irreversible T cell exhaustion limits the efficacy of programmed cell death 1 (PD-1) blockade. We observed that dual CD40-TLR4 stimulation within a single tumor restored PD-1 sensitivity and that this regimen triggered a systemic tumor-specific CD8+ T cell response. This approach effectively treated established tumors in diverse syngeneic cancer models, and the systemic effect was dependent on the injected tumor, indicating that treated tumors were converted into necessary components of this therapy. Strikingly, this approach was associated with the absence of exhausted PD-1hi T cells in treated and distant tumors, while s...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Active surveillance (AS) has been widely accepted as a first-line management approach in men with low-risk prostate cancer. While AS provides an avenue to reduce risk of overtreatment without compromising oncological safety, there remains a lack of consensus on the optimal approach to monitoring. An ideal surveillance strategy would be one that minimizes invasive testing such as prostate biopsy without conceding adverse oncologic outcomes. Thus, several studies have sought to identify men at higher risk of reclassification so as to more carefully select when biopsy is truly necessary.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
In “National trends in the utilization of androgen deprivation therapy for very low risk prostate cancer,” the authors demonstrate a significant decline in the use of primary androgen deprivation (pADT), for very low risk prostate cancer. By 2015, only 1.7% of men in this population received pADT, representing a furthering of trends witnessed in the early 21st century, and which have been previously described.1,2
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Hi everyone I failed a course by a single question (0.2%) and as a result I have to take a Remediation Exam. The exam is on our Fundamentals Course which is all of the basics sciences. It is 2 days away and I am starting to panic. It is on all of Immuno, all of BioChem, all Anatomy, all Micro, Anti-biotics, Anti-cancers, Anti-fungals, Fundamentals of Pathology, Infectious Disease and pretty much anything you can think of. I have been studying for a month but I feel like I just cant... Remediation Exam
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Medical Students - MD Source Type: forums
Conclusions: Adolescents diagnosed with asthma were more physically active than their non-asthmatic peers.RESUMO Objetivo: Avaliar o n ível de atividade física (AF) em asmáticos, comparando com não asmáticos, em estudo populacional. Métodos: Estudo transversal com adolescentes de 13 a 14 anos que participaram do estudo International Study of Asthma and Allergies in Childhood (ISAAC). Os indivíduos foram classificados em tr ês grupos: indivíduos com asma ativa, indivíduos com diagnóstico de asma e assintomáticos respiratórios. Para ava...
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
ABSTRACT Objective: To highlight the importance of the new classification criteria for the macrophage activation syndrome (MAS) in systemic juvenile idiopathic arthritis in order to reduce morbidity and mortality outcome related to this disease. Case description: A 12-year-old female patient with diagnosis of systemic juvenile idiopathic arthritis under immunosuppression therapy for two years developed cough, acute precordial chest pain, tachypnea, tachycardia and hypoxemia for two days. Chest tomography showed bilateral laminar pleural effusion with bibasilar consolidation. The electrocardiogram was consistent with acute ...
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
This study investigates the role of LAMC2 in epithelial-mesenchymal transition (EMT) and angiogenesis in CCA and explores the underlying mechanism(s) . Differentially expressed genes related to CCA were initially screened using a microarray analysis, and the interaction between LAMC2 and the EGFR signaling pathway was identified.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research
Conclusion We found a high economic impact of health care systems treating ICC in a poor region of Brazil. These estimates could be applicable to further evaluations of the cost-effectiveness of preventing and treating ICC.Resumo Objetivo O objetivo principal do presente estudo foi estimar os custos anuais por paciente do tratamento do c âncer do colo do útero (CCU) invasivo em um centro de oncologia no Brasil, sob a perspectiva da sociedade, considerando os custos diretos médicos, diretos não médicos e indiretos. Métodos Foi realizado um estudo descritivo de análise de custo...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Conclusion The role of OB-GYNs and of OB-GYNs ONCO appears to be complementary. Obstetricians and gynecologists actmore often in screening and prevention and in low-complexity surgical procedures, whereas OB-GYNs ONCO are more involved in highly complex cases. Strategies to raise standards in cancer training and to encourage the recognition of gynecologic oncology as a subspecialty should be adopted in Brazil.Resumo Objetivo Opresente estudotemcomo objetivo obter informa ções demográficas básicas, o nível de interesse e de treinamento em ginecologia oncológica entre obstetras e gin...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Source: International Journal of COPD - Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
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