Blood test predicts success of neuroendocrine cancer therapy

(Society of Nuclear Medicine) Malignant neuroendocrine tumors are relatively rare, notoriously difficult to treat, and associated with poor long-term survival. According to research presented at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, an investigative blood test could predict how patients will respond to peptide receptor radionuclide therapy before they commit to a course of treatment.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Abstract Self-hardening calcium phosphate cements present ideal bone tissue substitutes from the standpoints of bioactivity and biocompatibility, yet they suffer from (a) weak mechanical properties, (b) negligible osteoinduction without the use of exogenous growth factors, and (c) a lack of intrinsic antibacterial activity. Here we attempt to improve on these deficiencies by studying the properties of self-setting Fe-doped bone-integrative cements containing two different concentrations of the dopant: 0.49 and 1.09 wt% Fe. The hardening process, which involved the transformation of Fe-doped β-tricalcium pho...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
In this study, immunohistochemistry was performed to examine the expression of GARP and Foxp3 in 19 human PTC tissues (including 10 cases with and 9 cases without lymph node metastasis) and 20 benign thyroid diseases (including 10 cases with nodular goiter and 10 cases with adenoma). Compared with benign thyroid diseases, we found a significant increase in the expression of GARP in PTC. Increased GARP expression in PTC was positively correlated with increased expression of Foxp3, which is very important for development of Tregs. But, there is no significant association of elevated expression of GARP with lymph node metasta...
Source: Endocrine Pathology - Category: Pathology Source Type: research
In a move that will expand research and clinical trials, Roswell Park Comprehensive Cancer Center has announced a new academic agreement with one of Europe ’s oldest educational institutions. The collaboration with the Jagiellonian University (JU) in Kraków, Poland, will include exchanges of staff, students and scientific resources to advance the development of cancer therapies for patients worldwide. Effective immediately, the deal could see excha nge of students and faculty between the two centers…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
Authors: Shen T, Guo Q Abstract Proline-rich tyrosine kinase 2 (Pyk2) plays essential roles in tumorigenesis and tumor progression. Pyk2 serves as a non-receptor tyrosine kinase regulating tumor cell survival, proliferation, migration, invasion, metastasis, and chemo-resistance, and is associated with poor prognosis and shortened survival in various cancer types. Thus, Pyk2 has been traditionally regarded as an oncogene and potential therapeutic target for cancers. However, a few studies have also demonstrated that Pyk2 exerts tumor-suppressive effects in some cancers, and anti-cancer treatment of Pyk2 inhibitors m...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conclusion: XIST exerted regulatory function in resistance of DOX possibly through miR-124/SGK1 axis, shedding new light on developing promising therapeutic strategy to overcome chemoresistance in CRC patients.Cell Physiol Biochem 2018;51:113 –128
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Authors: Anand A, Balasubramanian D, Subramanian N, Murthy S, Limbachiya S, Iyer S, Thankappan K, Sharma M Abstract Secondary head and neck lymphedema (SHNL) is a chronic condition affecting patients who have undergone treatment for head and neck cancers. It results from the disruption of normal lymphatic flow by surgery and/or radiation. The incidence of secondary head and neck lymphedema varies anywhere between 12 and 54% of all patients treated for head and neck cancer, but it is still commonly under-diagnosed in routine clinical practice. In spite of awareness of this condition, treatment has been difficult as ...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
Contributors : Stephen C Mack ; Michael D Taylor ; Jeremy N RichSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGenome sequencing studies have uncovered the most frequent mutations in cancer and novel targets for therapy. While successful in many tumors, this approach has failed in others. Lethal infant ependymomas (Group A) lies at the far end of this spectrum with no recurrent focal genomic alterations, no recurrent somatic mutations, and no clear driver for targeted therapy. Despite a paucity of genetic aberrations, Group A ependymomas demonstrate widespread epigeneti...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
AbstractCurrent cancer therapy has led to tremendous improvements in outcomes. These therapies rely both on established therapies, such as anthracyclines and radiation, and molecularly-targeted therapies, such as tyrosine kinase inhibitors and immune modulators. Integrative care for patients with cancer must consider the potential effects of these therapies on a variety of organ systems, including the cardiovascular system. As a result, specialties such as cardio-oncology have developed to identify these effects, determine how to best monitor for these effects, and how to treat and ultimately prevent these effects while al...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy, Published online: 15 November 2018; doi:10.1038/s41416-018-0341-1High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: January 2019Source: Biomedicine &Pharmacotherapy, Volume 109Author(s): Sandeep Kumar, Navneet AgnihotriAbstractColorectal cancer (CRC) is the most common carcinoma of the digestive tract. The slow growing nature of CRC offers a great opportunity for prevention strategies. The concept of chemoprevention of colorectal cancer using plant derived natural products is gaining substantial attention because it is an inherently safe and cost-effective alternative to conventional cancer therapies. Piperlongumine (PL), a natural alkaloid present in Piper longum Linn has been reported to exhibit notable anticance...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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