Pretargeted radioimmunotherapy may eliminate colorectal cancer

An emerging cancer therapy has colorectal tumors surrounded. A novel radioimmunotherapy combines a cancer-seeking antibody with potent radionuclide agents, resulting in complete remission of colorectal cancer in mouse models.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: January 2019Source: Biomedicine &Pharmacotherapy, Volume 109Author(s): Sandeep Kumar, Navneet AgnihotriAbstractColorectal cancer (CRC) is the most common carcinoma of the digestive tract. The slow growing nature of CRC offers a great opportunity for prevention strategies. The concept of chemoprevention of colorectal cancer using plant derived natural products is gaining substantial attention because it is an inherently safe and cost-effective alternative to conventional cancer therapies. Piperlongumine (PL), a natural alkaloid present in Piper longum Linn has been reported to exhibit notable anticance...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
AbstractPurposePeripheral sensory neuropathy is the most prominently reported adverse effect of oxaliplatin. The purpose of this study was to evaluate metformin role in oxaliplatin-induced neuropathy.Patients and methodsFrom November 2014 to May 2016, 40 patients with stage III colorectal cancer completed 12  cycles of FOLFOX-4 regimen. Twenty patients in the control arm received FOLFOX-4 regimen only, and 20 patients in the metformin arm, received the same regimen along with metformin 500 mg three times daily. The metformin efficacy was evaluated using National Cancer Institute Common Terminology Cri teria for A...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
In this study, our aim to understand the potential molecular targets of diclofenac, which may propose new therapeutic targets in HCT 116 (wt p53) and SW480 (mutant p53R273H) colon cancer cells. For this purpose, we identified different response against diclofenac treatment through expression profiles of PI3K/Akt/MAPK signaling axis. Our hypothesis was diclofenac-mediated apoptosis is associated with inhibition of PI3K/Akt/MAPK signaling axis. We found that sub-cytotoxic concentration of diclofenac (400 µM) promoted further apoptosis in HCT 116 cells compared to SW480 colon cancer cells. Diclofenac triggered deph...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
Publication date: January 2019Source: Biomedicine &Pharmacotherapy, Volume 109Author(s): Lei Zhang, Liang Wang, Yufeng Wang, Tianxiang Chen, Runkun Liu, Wei Yang, Qingguang Liu, Kangsheng TuAbstractLong non-coding RNAs (lncRNAs) are critical regulators in the tumorigenesis and metastasis of hepatocellular carcinoma (HCC). LncRNA KTN1 antisense RNA 1 (KTN1-AS1) has been reported to play an important role in colorectal cancer and correlates with unfavorable clinical outcomes of head and neck squamous cell carcinoma. However, the clinical significance and functional role of KTN1-AS1 in HCC are still unclear. Here, we foun...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
We demonstrated that VB1 promoted apoptosis via p53 ‐dependent induction of p53 upregulated modulator of apoptosis (PUMA) and further to induce Bax activation and mitochondrial dysfunction in colon cancer HCT‐116 and LoVo cells. And we provide a novel insight for the antitcancer mechanism of VB1 and scientific rationale for further development of VB1 as a novel anticancer drug used alone or in combination with other chemotherapeutic agents in the treatment of colorectal cancer clinically. AbstractPurified vitexin compound 1 (VB1, a neolignan isolated and extracted from the seed of Chinese herb Vitex negundo) is an effe...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
The objective of the current review was to describe the role of energy balance on survival and the potential mechanisms of this relationship in patients with colorectal cancer (CRC).Recent FindingsEnergy balance consists of total energy expenditure and dietary intake over time, although these components have been sparsely characterized in CRC. Several large trials have suggested that BMI around 28  kg/m2 at diagnosis is most advantageous for survival and that severe weight loss (i.e., body mass index loss ≥ 7% or ≥ 10% baseline weight) is associated with poor survival. These patterns are likely due...
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research
Publication date: Available online 29 October 2018Source: Carbohydrate PolymersAuthor(s): O.S. Malyarenko, E.V. Zdobnova, A.S. Silchenko, M.I. Kusaykin, S.P. ErmakovaAbstractFucoidan from brown alga Fucus evanescens and its product of enzymatic hydrolysis have precisely established structure and possess significant biological activities.The aim of present study was to determine radiosensitizing activity of fucoidan from brown alga F. evanescens and its derivative in human melanoma, breast adenocarcinoma, and colorectal carcinoma cell lines and elucidate mechanism of their action.The fucoidan from F. evanescens and its deri...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Authors: Tang B, Liang W, Liao Y, Li Z, Wang Y, Yan C Abstract Liver metastasis is one of the major causes of death in patients with colorectal cancer, and although treatment has improved recently, the long‑term survival rate of patients has not improved significantly. In the present study, we used immunohistochemistry to determine that phosphoprotein enriched in astrocytes‑15 kDa (PEA15) was highly expressed in colorectal cancer tissues and liver metastatic cancer tissues. It was also highly expressed in metastatic colorectal cancer patients compared to non‑metastatic patients. Through clinicopathologic...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NFκB and/or caspase-3/7 signaling pathway. Oncol Lett. 2018 Nov;16(5):6140-6146 Authors: Zeng L, Qian J, Luo X, Zhou A, Zhang Z, Fang Q Abstract Colorectal cancer is a commonly observed malignant cancer. However, the limited therapies for colorectal cancer do not bring much benefit for patients. Chondroitin synthase-1 (CHSY1) is an enzyme responsible for the biosynthesis of chondroitin sulfate and has been implicated in the tumorigenesis of several cancer types; however, there is limited informati...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
AbstractPurpose of reviewThere is growing evidence to suggest that gut microbiota plays an important role in colorectal carcinogenesis. Western diet is associated with gut microbial dysbiosis, which leads to inflammation, oxidative stress, and genotoxic effects, all common risk factors for colorectal cancer.Recent findingsFusobacterium nucleatum,Helicobacter pylori,Bacteroides fragilis,Escherichia coli,and Streptococcus bovis are the main bacterial species associated with colorectal carcinogenesis. Gut microbiota transforms both diet- (meat, processed meat products, fat) and host (bile acids)-derived precursors into carcin...
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research
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