Blood test predicts success of neuroendocrine cancer therapy

Malignant neuroendocrine tumors are relatively rare, notoriously difficult to treat, and associated with poor long-term survival. An investigative blood test could predict how patients will respond to peptide receptor radionuclide therapy before they commit to a course of treatment.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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ONCOLOGY recently interviewed Dr. Eileen Parkes, whose laboratory studies the STING pathway, to find out why researchers are excited about targeting this pathway as a potential cancer therapy.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
We describe the development of supercharged fluorescent protein modified water-soluble poly (N-phenylglycine) nanoparticles (SPNPG/ScGFP) as a novel nanotheranostic agent with highly effective cell penetration for image-guided photothermal cancer therapy. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
This article provides an overview of AZD1775, based on English peer-reviewed articles on MEDLINE. The authors highlight the data from the published preclinical and clinical studies. Expert opinion: A majority of the current clinical trials focus on AZD1775 combined with chemotherapy or radiation. Treatment with AZD1775 was tolerated and antitumor activity has been observed, especially in patients with advanced malignancies harboring G1 checkpoint aberrations and/or DNA damage repair defects. Thus, identification of the molecular subtypes that benefit most from the treatment with AZD1775 alone or in combination may provide ...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
This study aimed to investigate the...
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
This study aimed to investigate the effect of Ru (Rut) on angiogenesis, and the underlying regulation mechanism of signal transduction. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, adhesion inhibition experiment, migration inhibition experiment, and chick embryo chorioallantoic membrane (CAM) assays were performed on models of angiogenesis. The potential targets of rutaecarpine (Ru) were reverse screened with Discovery Studio 2017. The interaction between the compound and target were detected by surface plasmon resonance (SPR), enzyme-activity experiment, and Western blot assay. The obtaine...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
i Kim Although many treatment strategies have been reported for lung disease, the mechanism of combination therapy using silver nanoparticles (AgNPs) and histone deacetylases inhibitors (HDACi) remains unclear. Therefore, innovative treatment strategies are essential for addressing the therapeutic challenges of this highly aggressive lung cancer. AgNPs and HDACi seem to be the best candidates for anticancer therapy because of their anti-proliferative effect in a variety of cancer cells. First, we synthesized AgNPs using wogonin as a reducing and stabilizing agent, following which the synthesized AgNPs were characterize...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Authors: Reid E, Suneja G, Ambinder RF, Ard K, Baiocchi R, Barta SK, Carchman E, Cohen A, Gupta N, Johung KL, Klopp A, LaCasce AS, Lin C, Makarova-Rusher OV, Mehta A, Menon MP, Morgan D, Nathwani N, Noy A, Palella F, Ratner L, Rizza S, Rudek MA, Taylor J, Tomlinson B, Wang CJ, Dwyer MA, Freedman-Cass DA Abstract People living with HIV (PLWH) are diagnosed with cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced cancer stage, comorbidities, immunosuppression, and cancer treatment disparities. Lack of guidelines and provider education has le...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
ConclusionNone of the treatment methods applied ensured a full release of the restriction within the shoulder and upper limb. The deficits observed may constitute a serious disorder of the musculoskeletal system; therefore, a clinical study of biomechanical parameters of the shoulder joint may be an important control of patients’ functional status after breast cancer treatment.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 13 August 2018Source: Radiation Physics and ChemistryAuthor(s): Ali Asghar Borran, Ayoub Aghanejad, Alireza Farajollahi, Jaleh Barar, Yadollah OmidiAbstractRadiation therapy is a regular treatment modality for the cancer therapy. Despite being a beneficial strategy, the radiation doses are limited, in large part because of the occurrence of inadvertent toxicity in the surrounding healthy tissues/organs. Among efforts to minimize the unwanted side effects in normal tissues and sensitize tumor tissues/organs to radiation, utilization of the high atomic number material such as noble metals (...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
Cytokine-based cancer therapies have attracted a great deal of attention in recent years. Unfortunately, resistance to treatment limits the efficacy of these therapeutics. Therefore, the aim of our study was t...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
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