Impact of Gastroesophageal Reflux and Aspiration on Airway Inflammation and Microbiome in Children With Chronic Cough

Conditions:   Chronic Cough (CC);   Gastroesophageal Reflux (GER)Interventions:   Procedure: Esophago-gastro-duodenoscopy (EGD) with biopsy;   Procedure: Esophageal Impedance Monitoring (EIM)Sponsor:   New York University School of MedicineNot yet recruiting - verified June 2016
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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ConclusionsAlthough semi-solid nutrients have several advantages, including reduced diarrhea and gastroesophageal reflux, evidence on semi-solid nutrients via the nasogastric tube is insufficient. It should be noted that semi-solid nutrient reflux can be more fatal than liquid nutrients.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionsAntireflux surgery, although less predictable, is effective for the treatment of gastroesophageal reflux disease-related chronic cough.
Source: Esophagus - Category: Gastroenterology Source Type: research
Conclusions: The prevalence of CC was lower than reported in previous studies. People with possible CC had higher rates of underlying conditions associated with CC. These observations may suggest poor recognition and/or under-recording of CC in primary care. PMID: 31558053 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
This study aimed to investigate the changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China, and to explore the clinical significance. Methods: Medical records of 1,311 patients with chronic cough who visit our hospital between January 2009 and December 2016 were retrospectively reviewed. The etiologies of chronic cough were identified according to a standardized step-by-step diagnostic protocol and the changes in the etiological frequency of chronic cough over the years were using the Chi-squared (χ2) test. Results: Cough variant asthma (CVA) (449/1,311, 34.2%), gastroesophage...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
CONCLUSIONS: NAEB, CVA, and UACS are common causes of chronic cough in patients with AR. FeNO can first be used to discriminate patients with CVA/NAEB, then FEF25-75 (or combined with FeNO) can further discriminate patients with CVA from those with CVA/NAEB. PMID: 31552718 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
A 6-month-old full-term male patient was born uneventfully through vaginal delivery. At the age of 3 months, he began experiencing unresolving dry cough and poor feeding. During respiratory auscultation, tachypnea without adventitious breath sounds was noted. Chest radiograph (CxR) based from the latest admission revealed ground-glass opacity (GGO) and hyperinflation in bilateral lung fields (Supplement Fig.). Meanwhile, echocardiogram showed a patent foramen ovale, while esophagogram was negative for tracheoesophageal fistula or gastroesophageal reflux.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Letter to the Editor Source Type: research
Abstract The Mysterious Cough - a Case-Based Proposal of Differential Diagnosis Abstract. Cough is a frequent complaint in the general practice. Avoidance of overdiagnosis and underdiagnosis is essential. In case of acute cough or subacute (8 week duration) and normal baseline examination and after cessation of smoking and medication with ACE-I, cough-variant asthma, gastro-esophageal reflux disease and upper airway cough syndrome are the main causes and should be assessed and empirically treated in a systematic manner. PMID: 31480953 [PubMed - in process]
Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
Conclusions: The common etiologies of chronic cough in school-age children were UACS, CVA, and PB, while EB and GERD were rare. PMID: 31463138 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. A 35-year-old man is evaluated during a follow-up appointment for persistent heartburn with chronic cough. He has a 1-year history of gastroesophageal reflux disease and takes pantoprazole twice daily. He reports no nausea, vomiting, or dysphagia. Upper endoscopy performed 1 year […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Gastroenterology Source Type: blogs
This article reviews the current literature regarding established and proposed EE-GERD, reporting on all available options for its correct diagnosis and therapeutic management. Expert opinion: MII-pH could help to identify a hidden GERD that causes EE. Unfortunately, standard MII-pH analysis results are often unable to define this association. New parameters such as the mean nocturnal baseline impedance and post-reflux swallow-induced peristaltic wave index may have an improved diagnostic yield, but prospective studies using impedance-pH are needed. PMID: 31322443 [PubMed - as supplied by publisher]
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
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