Application of electromembrane extraction followed by corona discharge ion mobility spectrometry analysis as a fast and sensitive technique for determination of tricyclic antidepressants in urine samples

Publication date: November 2016 Source:Microchemical Journal, Volume 129 Author(s): Zolfaghar Aladaghlo, Ali Reza Fakhari, Kobra Sadat Hasheminasab In the paper, electromembrane extraction (EME) method coupled with corona discharge ion mobility spectrometry (CD-IMS) was introduced for determination of antidepressant drugs (desipramine, sertraline, clomipramine, citalopram) in urine samples. IMS is a well-known, comparatively inexpensive, robust and easy to operate analytical instrumentation. This combination would provide a selective and sensitive determination. In order to achieve the best extraction efficiency, optimization of the variables affecting these methods was carried out. Optimal extractions were accomplished with 2-nitrophenyl octyl ether as the supported liquid membrane, with 190V as the driving force, and with pH4 in donor and pH1 in acceptor solutions. Extractions were obtained after 30min of operation with the whole assembly agitated at 1000rpm. Under the optimized conditions, the proposed technique provided good linearity (>0.9974), repeatability (RSD<4.5%), low limits of detection (0.9–1.5ngmL−1), excellent preconcentration factor (PF=158–190) and high recoveries (79–95%). Finally, developed method was applied to quantification of antidepressant drugs in urine samples.
Source: Microchemical Journal - Category: Chemistry Source Type: research