Extracted Anaxagorea luzonensis A. Gray Restored Impairment of Endothelium-Dependent Vasorelaxation Induced by Homocysteine Thiolactone in Rat Aortic Rings.

CONCLUSION: These results suggest that HTL-induced impairment of endothelium-dependent vasorelaxation may occur via decreased NO release, and generation of oxygen free radical. This study first shows that enhancement of TxA₂ production via COX-1 pathway is involved in HTL-induced endothelial dysfunctions. The protective effects of AL on impairment of relaxation by HTL may be related to increasing NO production and sulfhydryl-dependent. PMID: 27276830 [PubMed - in process]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - Category: Journals (General) Tags: J Med Assoc Thai Source Type: research