UC regents appoint Dr. Owen Witte University Professor

Dr. Owen Witte, renowned scientist and esteemed member of UCLA’s faculty, has been appointed a University Professor by the University of California Board of Regents. This appointment is reserved for scholars of the highest international distinction, who are respected as teachers of exceptional ability and whose contributions elevate the entire UC system. The University Professor title was established by the regents so that the entire UC system can benefit from the talents of outstanding faculty. Witte joins the ranks of just 40 UC faculty, including several Nobel laureates, who have received this honor since 1960. “Dr. Witte has made a significant impact at UCLA through his scientific achievements and visionary leadership,” said UCLA Chancellor Gene Block. “As University Professor, Witte’s efforts to unite and energize collaborative biomedical research across the UC system will only build upon his legacy — and further strengthen the competitiveness of our research enterprise.”   Witte’s accomplishments include impactful scientific discoveries, advocacy for science education funding and exemplary leadership as founding director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. His ability to create strategic partnerships across disciplines enables groups of elite clinicians, scientists and engineers to pursue breakthrough research with the shared goal of improving human health. Those...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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It is currently recognized that in addition to the major impact of human papillomavirus (HPV) infection in females, HPV causes considerable disease in men at the genitals, anal canal, and oropharynx. Specifically, genital HPV infections may progress to genital warts and penile carcinoma. Although studies concerning the natural history of HPV infections and associated neoplasias have mainly focused on women, during the last 2 decades considerable attention has been given in further understanding these infections in men. The HIM (HPV infection in men) Study, the only prospective multicenter study of male HPV natural history,...
Source: Acta Cytologica - Category: Cytology Source Type: research
Sexual intercourse is regarded as the primary route of human papillomavirus (HPV) transmission. Reported rates of the genotype-specific genital concordance of HPV infection among heterosexual partners vary. Most studies have evaluated only male/female genital transmission, but lately, the oral region has gained interest because of a rising trend of HPV-associated oropharyngeal cancer. Risk factors for type-specific concordance have been reported as an increasing number of younger couples, persistent HPV infection, higher frequency of sexual intercourse, rising number of spouse ’s lifetime sexual partners, and sexual ...
Source: Acta Cytologica - Category: Cytology Source Type: research
Publication date: 21 February 2019Source: Cell, Volume 176, Issue 5Author(s): Shashi Gujar, John Bell, Jean-Simon DialloOncolytic viruses (OVs) preferentially infect and kill cancer cells without harming normal cells. OVs can revert cancer-associated immune suppression and initiate clinically meaningful antitumor immune responses. OVs and their resultant immunological events can act at both primary and metastatic sites. Thus, OVs can be exploited for cancer gene therapies and immunotherapies alone or in combination with other interventions, including immune checkpoint blockade.
Source: Cell - Category: Cytology Source Type: research
Publication date: 21 February 2019Source: Cell, Volume 176, Issue 5Author(s): Ting Fu, Sally Coulter, Eiji Yoshihara, Tae Gyu Oh, Sungsoon Fang, Fritz Cayabyab, Qiyun Zhu, Tong Zhang, Mathias Leblanc, Sihao Liu, Mingxiao He, Wanda Waizenegger, Emanuel Gasser, Bernd Schnabl, Annette R. Atkins, Ruth T. Yu, Rob Knight, Christopher Liddle, Michael Downes, Ronald M. EvansSummaryIncreased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant trans...
Source: Cell - Category: Cytology Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
CANCER symptoms vary depending on which part of the body is affected by a tumour. You could be at risk of deadly tumour signs if you notice this feeling in your teeth. It could be a warning sign of deadly mouth cancer. Should you see a doctor?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Daisy Wyatt, 14, of Blackwood, Wales, finished treatment for rare bone cancer in 2016 after diagnosis at 12 years old. But the family were soon told it had spread to her lungs and was incurable.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, three non-linear indices consist of compression, one-dimensional (1D) and two-dimensional (2D) fractal dimensions are used for the determination of the malignancy or benignity of cancer tumours in breast thermograms. On the other hand, by developing the high-precision infrared cameras as well as new methods of image processing, biomedical thermography images have found a prominent position among the others. Furthermore, cancerous tissue can be affected by the laser. In this study, in order to treat the cancerous lesion identified by breast thermograms, the laser parameters are designed. The basis of controll...
Source: IET Systems Biology - Category: Biology Source Type: research
In this study, we sought to evaluate the risk of development of SPMs among CLL patients diagnosed from 2000-2014.Methods: We used the SEER 18 registries for the calculation of risk of SPMs and included CLL cases that were confirmed histologically between 2000-2014 (https://seer.cancer.gov/). SPMs diagnosed within 2 months of primary CLL diagnosis were excluded. Time to SPM was calculated by subtracting second malignancy survival/follow-up time from CLL survival/follow-up time. The SEER*Stat Multiple Primary-SIR tool was used to calculate SIRs for secondary malignancies by comparing these patients' subsequent cancer experie...
Source: Blood - Category: Hematology Authors: Tags: 904. Outcomes Research-Malignant Conditions: Poster II Source Type: research
Conclusions: Sepsis is associated with increased or decreased risks for a small group of cancers. Factors that may explain these associations include etiologic effects of bacterial infections, inflammation, or use of antibiotics. Other associations may reflect the presence of precursor conditions (e.g., cirrhosis, colorectal polyps) or patterns in ascertainment of cancer and screening. PMID: 29982318 [PubMed - as supplied by publisher]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Infect Dis Source Type: research
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