UC regents appoint Dr. Owen Witte University Professor
Dr. Owen Witte, renowned scientist and esteemed member of UCLA’s faculty, has been appointed a University Professor by the University of California Board of Regents. This appointment is reserved for scholars of the highest international distinction, who are respected as teachers of exceptional ability and whose contributions elevate the entire UC system. The University Professor title was established by the regents so that the entire UC system can benefit from the talents of outstanding faculty. Witte joins the ranks of just 40 UC faculty, including several Nobel laureates, who have received this honor since 1960. “Dr. Witte has made a significant impact at UCLA through his scientific achievements and visionary leadership,” said UCLA Chancellor Gene Block. “As University Professor, Witte’s efforts to unite and energize collaborative biomedical research across the UC system will only build upon his legacy — and further strengthen the competitiveness of our research enterprise.” Witte’s accomplishments include impactful scientific discoveries, advocacy for science education funding and exemplary leadership as founding director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. His ability to create strategic partnerships across disciplines enables groups of elite clinicians, scientists and engineers to pursue breakthrough research with the shared goal of improving human health. Those...
The objective of this study was to evaluate the structural integrity and infectivity of Ap after lysis of the host cells using rock tumbler grit and to compare the outcome to that of the frequently used method, syringe lysis. Human promyelocytic leukemia cell lines (HL-60) were infected with Ap and following host cell-free bacteria were assessed by transmission electron microscopy. The outcome of the different purification methods was compared using live/dead-staining based on immunofluorescence to count the number of viable bacteria and real-time PCR to compare the amount of DNA. Subsequently the isolated bacteria were te...
CONCLUSIONS Our study demonstrated that FEZF1-AS1 exerted an oncogenic role in ovarian cancer via modulating JAK-STAT3 pathway. PMID: 30416194 [PubMed - in process]
Authors: M R, S V, Ramirez JT, A V, L L Abstract Novel materials are explored very often by material scientists to design an efficient drug delivery system to target carcinoma cells. Among various nanosystem, functionalized Iron oxide Nanoparticles (IoNP) were definitely studied especially to target, endocyte and release drug moieties inside the cells. This IoNP platform is usually composed of an inorganic core and a highly biocompatible shell layer in order to perform numerous tasks at the same time, such as drug delivery, multimodal imaging, and instantaneous monitoring, along with collective therapeutic approach...
ConclusionOur results indicated that based on fecal bacterial candidates, statistical simple linear combination model and ROC curve analysis, early detection of AP and CRC might be possible.
PMID: 30420077 [PubMed - in process]
Abstract Melanoma is a potentially aggressive skin cancer with a steadily rising incidence. Most melanomas are diagnosed at an early stage and associated with an excellent prognosis when treated appropriately. Primary treatment for melanoma is surgical. Wider surgical margins and a variety of techniques for comprehensive histologic margin assessment may be considered for lentigo maligna type melanoma on the head and neck, due to characteristic broad subclinical extension. For invasive melanoma, sentinel lymph node biopsy may be indicated for staging, and to guide further management and follow-up. Appropriate treat...
Abstract Radiotherapy plays a role in the definitive or adjuvant management of early and late stage skin cancers including nonmelanoma basal cell carcinoma and cutaneous squamous cell carcinoma, melanoma, and Merkel cell carcinoma. The role of radiotherapy in skin cancers of the head and neck is reviewed including early and advanced-stage nonmelanoma skin cancers, melanoma, and Merkel cell carcinoma. In particular, the indications, oncologic outcomes, and technical aspects of radiotherapy for these diseases are discussed. PMID: 30420066 [PubMed - in process]
Toronto's St. Michael's Hospital is marking the 50th anniversary of Canada's first successful heart transplant. "We showed that it can be done," remembered a doctor involved in the landmark surgery.
BLOATED stomach pain is most commonly caused by trapped wind, but can also be a symptom of stomach cancer. How do you know if bloating indicates cancer?
Conclusions: Sepsis is associated with increased or decreased risks for a small group of cancers. Factors that may explain these associations include etiologic effects of bacterial infections, inflammation, or use of antibiotics. Other associations may reflect the presence of precursor conditions (e.g., cirrhosis, colorectal polyps) or patterns in ascertainment of cancer and screening. PMID: 29982318 [PubMed - as supplied by publisher]
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