Nuclear organization of the substantia nigra, ventral tegmental area and retrorubral field of the common marmoset (Callithrix jacchus): A cytoarchitectonic and TH-immunohistochemistry study

Publication date: Available online 9 June 2016 Source:Journal of Chemical Neuroanatomy Author(s): José R.L.P. Cavalcanti, André L.B. Pontes, Felipe P. Fiuza, Kayo D.A. Silva, Fausto P. Guzen, Eudes E.S. Lucena, Expedito S. Nascimento-Júnior, Judney C. Cavalcante, Miriam S.M.O. Costa, Rovena C.G.J. Engelberth, Jeferson S. Cavalcante It is widely known that the catecholamine group is formed by dopamine, noradrenaline and adrenaline, whose synthesis is regulated by the enzyme called tyrosine hydroxylase. Thus, 3-hydroxytyramine/dopamine (DA) is a precursor of the noradrenaline and adrenaline synthesis and acts as a neurotransmitter in the central nervous system. The three main nuclei, named retrorubral field (A8 group), substantia nigra pars compacta (A9 group) and ventral tegmental area (A10 group), are arranged in the die-mesencephalic portion and are involved in three complexes circuitries – the mesostriatal, mesolimbic and mesocortical pathways. Such pathways are involved in behavioral manifestations, motricity, learning, reward and also in pathological conditions such as Parkinson’s disease and Schizophrenia. Thus, the aim of this study is to perform a morphological analysis of the A8, A9 and A10 groups in the common marmoset (Callithrix jacchus), a neotropical primate, whose morphological and functional characteristics supports the suitability of its use in biomedical research. Coronal sections of the marmoset brain were submit...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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Authors: Desmettre T Abstract Nearly one-third of the planet's population is affected by Toxoplasma gondii infection. In ophthalmology, toxoplasmosis is even considered to be the most common cause of posterior uveitis of infectious origin. Humans are only an intermediate host and T. gondii needs to infect cats for its sexual reproduction. All the elements increasing the risk of predation by the definitive host are then favourable to the parasite. Numerous experimental animal model studies have shown that T. gondii infection is associated with predatory risk behaviours such as an attraction of infected mic...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Childhood abuse and neglect predicts suicide attempt. Furthermore, other early-life stressful events may predict lifetime suicide attempt in psychiatric disorders. We assessed 189 schizophrenics for suicide attempt and stressful life events. Early-life str...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Schizophrenia (SCZ) is associated with an increased risk of violence compared to the general population. Previous studies have indicated smaller hippocampal and amygdala volumes in violent than non-violent psychotic patients. However, little is ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
  Rich celebrity on TV: “Have you ever been sad? You might have depression.” If scenarios like this make you want to throw a rock at a window, you aren’t alone. In today’s episode, Gabe expresses his distaste for celebrities posing as the “face” of mental illness. He feels further validated after watching a satirical episode of BoJack Horseman, in which Mr. Peanutbutter, a cheerful canine celebrity, becomes the new face of depression — first as a “sad dog” meme and then as a depression spokesperson. What do you think? Tune in to hear Jackie and Gabe get into a ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Celebrities Depression Disorders General Mental Health and Wellness Not Crazy Podcast Source Type: blogs
Authors: Tesli N, van der Meer D, Rokicki J, Storvestre G, Røsæg C, Jensen A, Hjell G, Bell C, Fischer-Vieler T, Tesli M, Andreassen OA, Melle I, Agartz I, Haukvik UK Abstract Schizophrenia (SCZ) is associated with an increased risk of violence compared to the general population. Previous studies have indicated smaller hippocampal and amygdala volumes in violent than non-violent psychotic patients. However, little is known about volumetric differences at the subdivision level of these structures. In the present study, hippocampal subfields and amygdala nuclei volumes were estimated with FreeSurfer from...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This article presents a longitudinal case study of a woman in her early 40s with a primarily right hemisphere TBI and disorder of the self who had difficulties relating her experiences from the perspective of the self. Subjective interviews, neuropsychological test scores, and objective personality testing illustrate how she reported her experiences of a diminished sense of self, and how this sense of self improved over the normal course of recovery following the TBI. This case demonstrates clinically relevant information regarding how individuals with a reduced "sense of self" (i.e., "mineness") associ...
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
Publication date: Available online 25 January 2020Source: NeuroImageAuthor(s): Franziska Weiss, Vera Zamoscik, Stephanie N.L. Schmidt, Patrick Halli, Peter Kirsch, Martin Fungisai GerchenAbstractReal-time functional magnetic resonance imaging neurofeedback (rtfMRI NFB) is a promising method for targeted regulation of pathological brain processes in mental disorders. But most NFB approaches so far have used relatively restricted regional activation as a target, which might not address the complexity of the underlying network changes. Aiming towards advancing novel treatment tools for disorders like schizophrenia, we develop...
Source: NeuroImage - Category: Neuroscience Source Type: research
ConclusionMDD seems to be highly prevalent, underdiagnosed and undertreated in BD and SZ homeless subjects. Beyond antidepressants, add-on strategies including complementary agents, lithium, lamotrigine/carbamazepine or anti-inflammatory drugs and the specific care of alcohol and substance use disorders may be recommended to improve the prognosis of this specific population in addition to other interventions including housing and resocialization. Violent victimization is also frequent and should be specifically prevented in this vulnerable population.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Treatment-refractory psychosis (TRP) is a controversial term in the setting of the current societal stigma and medical understanding or misunderstanding of mental illness. However, there is recognition that patients with either advanced mental illness (i.e. schizophrenia) in the setting of terminal diseases such as cancer or certain neurologic diseases (i.e. Huntington's disease and Lewy body dementia) can result in psychotic states not amendable to conventional pharmacologic and non-pharmacologic treatments.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
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