Left ventricular function during porcine-resuscitated septic shock with pre-existing atherosclerosis.

CONCLUSIONS: The data of the present study are in conflict with previously published data from healthy animal models, most likely as a result of ongoing resuscitation including noradrenaline treatment or intrinsic pathophysiologic processes of the pre-existing atherosclerosis. Moreover, increased nitrotyrosine formation and decreased expression of CSE suggest the implication of augmented oxidative/nitrosative stress and/or reduced bioavailability of nitric oxide as well as diminished endogenous H2S release in the pathophysiology of septic cardiomyopathy.
PMID: 27271248 [PubMed]

Source: Atherosclerosis - June 10, 2016 Category: Cardiology Authors: Nußbaum BL, McCook O, Hartmann C, Matallo J, Wepler M, Antonucci E, Kalbitz M, Huber-Lang M, Georgieff M, Calzia E, Radermacher P, Hafner S Tags: Intensive Care Med Exp Source Type: research