Complicated urinary tract infections: ceftolozane/tazobactam

This advice outlines how in a randomised controlled trial in adults with complicated urinary tract infections or acute pyelonephritis, an intravenous infusion of ceftolozane/tazobactam was found to be non‑inferior to IV levofloxacin for the composite outcome of microbiological eradication of all baseline uropathogens and clinical cure. In 2 RCTs in people receiving ceftolozane/tazobactam for complicated urinary tract or intra-abdominal infections.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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AbstractPurposeUrinary tract infections (UTI) are one of the most common reasons for prescribing antibiotics in primary care. In Switzerland, the Swiss Center for Antibiotic Resistances (ANRESIS) provides resistance data by passive surveillance, which overestimates the true resistance rates. The aim of this study was to provide actual data of the antimicrobial resistance patterns in patients with UTI in Swiss primary care.MethodsFrom June 2017 to August 2018, we conducted a cross-sectional study in 163 practices in Switzerland. We determined the resistance patterns of uropathogens in patients with a diagnosis of a lower UT...
Source: Infection - Category: Infectious Diseases Source Type: research
ConclusionsOur estimates illustrate that antibiotic choices can be different between HAUTI conditions. Findings can improve empirical antibiotic selection towards a personalized approach but should be validated in local surveillance studies.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 19 September 2019Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Tiernan Connor Middleton, Dennis Drehner, Monica Epelman, Tamarah J. Westmoreland, Adela Casas-Melley, Pamela EllsworthAbstractRenal masses in the pediatric population carry a wide differential diagnosis; however, a careful history and physical can often elucidate the source. Infectious, benign, and malignant causes should all be considered in a patient presenting with a renal mass to mitigate risks of treatment options and safely ameliorate the patient's pathology. Pediatric renal masses are rare. Renal malignan...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Amer J Perinatol DOI: 10.1055/s-0039-1696721 Objective Our primary objective was to identify risk factors for maternal readmission with sepsis. Our secondary objectives were to (1) assess diagnoses and infecting organisms at readmission and (2) compare early (
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: SMFM Fellowship Series Article Source Type: research
Here, we investigated omptin protease ‐mediated antimicrobial resistance among uropathogenicEscherichia coli clinical isolates. We found that clinical isolates with the highest omptin protease activity encode multiple omptin proteases, showing different substrate specificities. Our data suggest that the presence of multiple omptin family proteases in a single clinical isolate may provide a fitness advantage by expanding the range of natural antimicrobial peptides cleaved during urogenital tract colonization. AbstractBacterial colonization of the urogenital tract is limited by innate defenses, including the production of ...
Source: MicrobiologyOpen - Category: Microbiology Authors: Tags: SPECIAL ISSUE: ANTIMICROBIAL RESISTANCE Source Type: research
In this edition of Mythbusters we critically examine the premise that, because women with history of vesicoureteric reflux (VUR) are at higher risk of urinary tract infection (UTI) and other morbidity during pregnancy, persistent VUR in older girls should be considered an indication for surgical correction. The literature is very limited in that there are essentially no methodologically robust comparisons of pregnancy outcomes among women whose childhood VUR was or was not surgically repaired. Most of the case series and cohorts find relatively high incidence of UTI and pyelonephritis among pregnant women with a history of...
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Tags: Editorial Source Type: research
ConclusionsIn this retrospective analysis of our clinical experience treating CRE infections in an LTACH setting, we documented that CRE infections occur in patients with substantial comorbidities. Although clinical outcome remains of great concern, the 28-day mortality and rate of eradication of CRE in this study were comparatively better than other national estimates. Inappropriate empiric treatment may be one of many factors leading to overall poor treatment outcomes.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Contributors : Katherine Xu ; Tian H Shen ; Atlas Khan ; Nicholas Tatonetti ; Krzysztof Kiryluk ; Jonathan BaraschSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe kidney and bladder expresses a variety of powerful defense mechanisms to limit urinary infection including iron scavenging, a process called "nutritional immunity". We previously demonstrated that bladder and kidney epithelia generates the archetype of the urinary iron defense, a lipocalin called NGAL which binds Enterochelin, a bacterial siderophore. However, because urinary bacteria can evade the bacteriostati...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Conclusion: In a large cohort of patients seen in routine clinical practice, risk for severe and nonsevere UTI events among those initiating SGLT-2 inhibitor therapy was similar to that among patients initiating treatment with other second-line antidiabetic medications. Primary Funding Source: Brigham and Women's Hospital, Division of Pharmacoepidemiology and Pharmacoeconomics. PMID: 31357213 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
Abstract PURPOSE: We aim to identify the prevalence and risk factors of three outcomes after stone removal following treatment for obstructive acute pyelonephritis (APN) associated with urinary tract calculi: immediate postoperative febrile urinary tract infection (UTI), stone recurrence, and APN recurrence during the follow-up period. MATERIALS AND METHODS: We retrospectively review the charts of 107 patients who underwent stone removal following treatment for obstructive APN associated with urinary tract calculi. Logistic regression analysis is used to identify the factors that contribute to postoperative f...
Source: Urology Journal - Category: Urology & Nephrology Authors: Tags: Urol J Source Type: research
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