Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis

Conclusions The pregnancy outcomes reported in this small number of RA/psoriasis patients appear similar to those observed in the general population and in patients treated with biologic therapies for inflammatory diseases. However, definitive conclusions cannot be drawn, and pregnancy outcomes in patients receiving tofacitinib will continue to be monitored.
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research

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UK-based biopharma company Izana Bioscience said it was testing its antibody therapy namilumab for the treatment of patients with rapidly worsening COVID-19 at the Humanitas Research Hospitals in Bergamo and Milan in Italy.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
ConclusionNon-adherence to mesalamine was underestimated by physicians in pregnant UC patients and contributed to disease relapse and possibly on pregnancy outcomes. Preconceptional education regarding safety of medications and risk of self-discontinuation is warranted.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Publication date: Available online 4 April 2020Source: Journal de Mycologie MédicaleAuthor(s): Elie Djenontin, David Lebeaux, Hans Acikgoz, Blandine Rammaert, Marie-Elisabeth Bougnoux, Claire Rouzaud, Benjamin Bouyer, Benoit Champigneulle, Eric Dannaoui
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: Available online 5 April 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Ayala Zilberman, Vered Eisenberg, Rakefet Yoeli, David Soriano, Eyal Sivan, Gil Golan, Roy Mashiach
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 4 April 2020Source: Case Reports in Women's HealthAuthor(s): Peter Khamvongsa, Naiya Patel, Ayesha Aziz Ali, Nikita Bodoukhin, Octavio Carreno
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
As much of the world settles into a new routine of social distancing, couples are likely to have a lot more free time to snuggle at home together. But there could be a number of risks in trying to get pregnant right now.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional study was conducted on women with GH hospitalized in hospitals affiliated with Mashhad University of Medical Sciences, compared with healthy women admitted for normal delivery in the same centers during the study. Data were collected via Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto-questionnaire (TEMPS-A) and Depression Anxiety Stress Scale (DASS) 21.Results: TEMPS-A revealed that scores anxious (P
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Conclusion: This study provides evidence for blood pressure management in Chinese pregnant women. PMID: 32243195 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Contributor : Daniel VaimanSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe STOX1 transcription factor has been involved in a complex human disease of pregnancy, preeclampsia, in human families, and mouse models. However, its mode of action is still largely unknown. Overexpression of either the long (STOX1A) or the short (STOX1B) isoform was obtained in the BeWo villous trophoblast model, a cell line able to fuse in syncytiotrophoblast following induction by forskolin treatment. The effects at the transcriptional level are evaluated in every condition.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Conclusion Although data are limited and all known exposures have occurred in the first trimester, no increased risk of fetal abnormalities or adverse pregnancy outcomes associated with gestational exposure to DMF has been observed. Funding Biogen, Inc.
Source: Neurology and Therapy - Category: Neurology Source Type: research
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