Adverse effects of extracorporeal carbon dioxide removal (ECCO 2 R) for acute respiratory failure: a systematic review protocol

Discussion In the UK, the current access to the use of ECCO2R is possible only with special arrangements for clinical governance, consent and for audit or research. Current evidence on ECCO2R suggests that there are a number of well-recognised complications which vary greatly across studies. This systematic review will consolidate the existing knowledge on adverse effects resulting from the use of ECCO2R. Systematic review registration PROSPERO CRD42015023503.
Source: Systematic Reviews - Category: Global & Universal Source Type: research

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Condition:   Transplantation Lung Interventions:   Other: Tailored tacrolimus dosing;   Other: Conventional tacrolimus dosing Sponsor:   Philipps University Marburg Medical Center Not yet recruiting
Source: - Category: Research Source Type: clinical trials
ConclusionsManagement of delivery in cases of suspected autosomal recessive renal polycystic kidney disease needs to be discussed because of the risk of abdominal dystocia. The route and timing of delivery depend on the size of the fetal abdominal circumference and the gestational age. The rate of kidney growth must also be taken into account.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue when healing is complete.However, when healing is disrupted — whether by chronic injury or disease — the cells that make up scar tissue can go rogue, continuously dividing and spreading until the scar eventually strangles the organ it was intended to help heal, which can lead to organ failure.That progressive, out-of-control scarring is called fibrosis, and it can occur in any organ in the body. Fibrosis plays a major role in many dis...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Authors: Montgomery E, Macdonald PS, Jha SR, Newton PJ, Malouf M PMID: 31815560 [PubMed - as supplied by publisher]
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
AbstractThe calcineurin inhibitor tacrolimus is an effective immunosuppressant and is extensively used in solid organ transplantation. In the first week after heart and lung transplantation, tacrolimus dosing is difficult due to considerable physiological changes because of clinical instability, and toxicity often occurs, even when tacrolimus concentrations are within the therapeutic range. The physiological and pharmacokinetic changes are outlined. Excessive variability in bioavailability may lead to higher interoccasion (dose-to-dose) variability than interindividual variability of pharmacokinetic parameters. Intravenous...
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Dylan Mortimer creates celestial and glittery interpretations of scars, lungs and operating rooms.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 7 December 2019Source: The Lancet HaematologyAuthor(s): Kris M Mahadeo, Rajinder Bajwa, Hisham Abdel-Azim, Leslie E Lehmann, Christine Duncan, Nicole Zantek, Jennifer Vittorio, Joseph Angelo, Jennifer McArthur, Keri Schadler, Sherwin Chan, Priti Tewari, Sajad Khazal, Jeffery J Auletta, Sung Won Choi, Basirat Shoberu, Krzysztof Kalwak, Avis Harden, Partow Kebriaei, Jun-ichi AbeSummarySinusoidal obstructive syndrome, also known as hepatic veno-occlusive disease, is a potentially life-threatening complication that occurs in children undergoing haemopoietic stem-cell transplantation (HSCT). D...
Source: The Lancet Haematology - Category: Hematology Source Type: research
Bronchiolitis obliterans syndrome (BOS) is a devastating complication of allogeneic hematopoietic cell transplant (allo-HCT) and is associated with significant morbidity and mortality. BOS is usually not diagnosed until patients present with respiratory symptoms, at which point airflow obstruction is already advanced [1,2]. Detecting an early decline in lung function is challenging as it is often asymptomatic [3,4]. Once established, patients can experience progressive and irreversible respiratory impairment, repeated lung infections, and increased risk of non-relapse mortality [5 –7].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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