Multi-detector computed tomography (MDCT) findings of chemotherapy induced hepatic changes

Publication date: Available online 4 June 2016 Source:The Egyptian Journal of Radiology and Nuclear Medicine Author(s): Sieza Samir Abd-Allah, Ahmad El-Morsy, Adel El-Badrawy, Magdy Settein, Shahira El-Etreby, Amal Halim, Tawfik Elkhodary, Sameh M. Abdel Monem Purpose To evaluate the role of multi-detector computed tomography (MDCT) in detection and characterization of chemotherapy induced hepatic changes. Materials and methods This retrospective study included 400 patients with confirmed 14 malignancies and treated by standard chemotherapy regimens. The most common malignancy was non-Hodgkin lymphoma and mostly chemotherapy regimen was Cyclophosphamide, Hydroxydaunomycin, Oncovin and Prednisolone (CHOP). All patients underwent CT scan using 64 MDCT scanner (Brilliance 64, Philips) before chemotherapy and follow-up after 6months from last session of chemotherapy. Precontrast series and post-contrast triphasic study were done for all patients. All the patients underwent radiological evaluation for hepatic changes after chemotherapy treatment. All CT scans were evaluated for fatty liver, capsular retraction, venoocclusive disease and biliary sclerosis. Four patients with capsular retraction underwent liver biopsy. Results Forty patients (32 females and 8 males) had hepatic changes due to effect of chemotherapy. The most common CT finding was fatty liver. Hepatic fatty changes were detected in 36/40 patients. These fatty changes were diffuse, focal fatty ...
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research