Connections between sleep and Alzheimer's disease : Insomnia, amnesia and amyloid.

[Connections between sleep and Alzheimer's disease : Insomnia, amnesia and amyloid]. Nervenarzt. 2016 Jun 1; Authors: Busche MA, Kekuš M, Förstl H Abstract Sleep plays an essential role in memory consolidation. Although sleep problems are common in Alzheimer's disease, they are not usually thought to be key features of the disease; however, new experimental research has shown that sleep disturbances not only occur before the onset of typical cognitive deficits but are also associated with the pathogenesis of Alzheimer's disease and may have a decisive influence on the symptoms and course. Thus, sleep disturbances may be potentially modifiable risk factors for Alzheimer's disease that deserve more attention in research, diagnostics and treatment. PMID: 27251738 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research

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In conclusion, these results indicated that loganin produced beneficial sedative and hypnotic activity, which might be mainly mediated by modification of the serotonergic system and GABAergic neurons. Introduction Insomnia is referred to as continuous difficulty in initiating or maintaining sleep, which can induce extreme medical and psychiatric disorders (Cao et al., 2016). It was reported that 27 percent of people in the world suffering from insomnia (Doghramji, 2006), and approximately 3–10 percent of people would frequently depend on hypnotics to overcome insomnia by 2050 (Chu et al., 2007). Clinically, b...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsDifferent patterns of sleep disturbances are observed in HD patients: insomnia, difficulties in falling asleep, frequent nocturnal awakenings, and excessive daytime sleepiness are the most common sleep problems reported by patients with HD. In several HD studies, specific changes in sleep architecture and in circadian melatonin secretion were identified in laboratory testing.Sleep disorders in HD have diverse and complex determinants, the most significant of which includes damage to brain areas that are responsible for the proper sleep pattern and circadian rhythm regulation. Sleep and circadian rhythm disorders...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In conclusion, our results suggest that PF lead high hippocampal neurogenesis in the animals even in inherited sleep-disturbed animals. The increased hippocampal neurogenesis functionally enhanced memory and learning functions by repeated PF oral administration. These results identify PF as a potential therapy for enhancing memory functions and prevention of Alzheimer's disease through actions on the hippocampus.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
In conclusion, our results suggest that PF lead high hippocampal neurogenesis in the animals even in inherited sleep-disturbed animals. The increased hippocampal neurogenesis functionally enhanced memory and learning functions by repeated PF oral administration. These results identify PF as a potential therapy for enhancing memory functions and prevention of Alzheimer's disease through actions on the hippocampus.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
This study is part of a growing body of research that suggests a sleep-deprived brain might be more vulnerable to Alzheimer’s disease. Animal studies have shown levels of plaque-forming A-beta plummet during sleep. Other research points to the fact that a sleeping brain runs the “clean cycle” (a reference to a dishwasher) to remove the day’s metabolic debris, specifically A-beta plaques. A study done in 2017 found that even one sleepless night appears to leave behind an excess of the troublesome protein fragment. While this is all impressive research, scientists believe there are still plenty of gap...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Health-related Mental Health and Wellness Research Sleep Alzheimer's disease Dementia Source Type: blogs
My grandfather was a true Yankee farmer. Taciturn and dignified, he rarely said a paragraph when a few words would do. Once, when I was in my mid-twenties and totally clueless about what it means to be dealing with old age, I found him sitting at the kitchen table translating poetry from German to English. Then in his late 70s, it had been over 50 years since he took basic German at the agricultural college he attended. I didn’t have any idea he knew even one German phrase. Yet there he was, diligently working out the poem, word by word by word. “Why don’t you just get an English translation?” I as...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Health-related Memory and Perception Self-Help Cognitive Function Memory Loss Source Type: blogs
This study is the clearest demonstration in humans that sleep disruption leads to an increased risk of Alzheimer’s disease through an amyloid beta mechanism,” said senior author Randall Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology. “The study showed that it was due to overproduction of amyloid beta during sleep deprivation.”More than 5 million Americans are living with Alzheimer ’s, a disease characterized by gradual memory loss and cognitive decline.What is the Difference Between Alzheimer ’s and DementiaThis study indicatesthat sleeping poorly...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: health lack of sleep alzheimer's lack of sleep dementia poor sleep linked to alzheimer Source Type: blogs
It’s amazing how a good night’s sleep can rejuvenate the mind, or “rest the little grey cells” as Hercule Poirot, Agatha Christie’s famed sleuth, liked to say. But sound slumber may boost the brain another way by protecting you against Alzheimer’s disease. Research has begun to show an association between poor sleep and a higher risk of accumulating beta-amyloid protein plaque in the brain, one of the hallmarks of the disease. “Observational studies have found that adults over age 65 with amyloid plaques in their brain have reduced slow-wave sleep, which is thought to play an impor...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Behavioral Health Brain and cognitive health Healthy Aging Memory Sleep Source Type: blogs
This article was originally published on Recovery Brands' Pro Talk/Pro Corner http://www.rehabs.com/pro-talk-articles/yes-benzos-are-bad-for-you/ Allen Frances is a professor emeritus at Duke University and was the chairman of the DSM-IV task force. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Science - The Huffington Post - Category: Science Source Type: news
By Brandon R. Peters, M.D. The news was enough to give you indigestion: Some of the over-the-counter and prescription medications most widely used to treat heartburn and acid reflux are linked to the development of dementia. The research suggesting a possible association is the latest in a string of implicated drugs over the past few years, including medications taken to treat anxiety, seizures, insomnia, and allergies. What is going on? Before emptying out the medicine cabinet, take a moment to consider the role of untreated obstructive sleep apnea. Scientific research can be difficulty to contextualize, especially when i...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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