CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism

Conclusions
Our data show that deletion of CD248 reduces susceptibility to liver fibrosis via an effect on PDGF signalling, making it an attractive clinical target for the treatment of liver injury.

Source: Gut - June 2, 2016 Category: Gastroenterology Authors: Wilhelm, A., Aldridge, V., Haldar, D., Naylor, A. J., Weston, C. J., Hedegaard, D., Garg, A., Fear, J., Reynolds, G. M., Croft, A. P., Henderson, N. C., Buckley, C. D., Newsome, P. N. Tags: Cirrhosis, Open access Hepatology Source Type: research