Serrated polyposis syndrome: risk stratification or reduction?

Serrated polyposis syndrome (SPS; formerly ‘hyperplastic polyposis syndrome’) has emerged as by far the most common colorectal polyp syndrome.1 2 SPS is characterised by some combination of large and/or numerous serrated class lesions and is associated with an increased risk of colorectal cancer (CRC).3 A genetic basis for SPS has not yet been discovered, and many cases do not have a family history of SPS or even CRC. Thus, any current definition of SPS must be clinical and based on colonoscopic findings and the pathology of polyps removed during colonoscopy. Most clinicians accept the WHO criteria for diagnosis of SPS as reasonable working criteria for clinical studies as well as clinical practice. The WHO proposes three criteria, and satisfaction of any of the three criteria is sufficient to diagnose SPS (box 1). It is critical that clinicians understand that ‘serrated class’...
Source: Gut - Category: Gastroenterology Authors: Tags: Commentary Source Type: research