Drug Safety Monitoring in Children: Performance of Signal Detection Algorithms and Impact of Age Stratification

Conclusion The performance of the two tested SDAs was similar in the pediatric population. Age adjustment does not improve performance and is therefore not recommended to be performed routinely. Stratification can reveal new associations, and therefore is recommended when either drug use is age-specific or when an age-specific risk is suspected.

http://link.springer.com/10.1007/s40264-016-0433-x

Source: Drug Safety - June 1, 2016 Category: Drugs & Pharmacology Source Type: research