The “Unusual Suspects” in Allograft Rejection: Will T Regulatory Cell Therapy Arrest Them?

Abstract Several trials with adoptively transferred T regulatory cells (TRegs) have shown to be safe and—in some instances—to be effective in patients with hematological malignancies after allogeneic hematopoietic stem cell transplantation (to prevent graft-versus-host disease), with type 1 diabetes (to preserve residual beta cell function), and with refractory Crohn’s disease (to control the disease). In solid organ transplantation, TReg-cell therapy trials with TReg-supportive immunosuppression are currently being undertaken to control the well-documented T effector cells responsible for allograft rejection. Emerging reports show that many “unusual suspects” are involved in allograft rejection as well. Whether TReg-cell therapy will also target them remains to be investigated. In this review, we will shed some light on these underscored cells, the role TRegs would potentially have in controlling these unusual suspects, and the immune-monitoring strategies that would address potential TReg-cell therapy efficacy.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening hypoglycemia during starvation-like conditions, but do not consistently exhibit overt metabolic phenotypes when given ad libitum food access. These results, and findings of ghrelin resistance in obese states, imply nutritional state dependence of ghrelin’s metabolic actions. Here, we hypothesized that liver-enriched antimicrobial peptide-2 (LEAP2), a recently characterized endogenous GHSR antagonist, blunts ghrelin action during obese states and pos...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
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Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
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Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Food & Function Source Type: research
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Source: NHS Networks - Category: UK Health Source Type: news
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Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Diabetes Technology - Category: Endocrinology Authors: Source Type: research
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