Comparing Glutamatergic Neuron Population in the Mediodorsal Thalamic Nucleus of Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and Normal Control Wistar Rats

Publication date: Available online 1 June 2016 Source:Journal of Chemical Neuroanatomy Author(s): Safiye Çavdar, Merve Özgür, Özlem Kirazlı, Serçin Karahüseyinoğlu, Filiz Onat An imbalance between GABAergic inhibition and glutamatergic excitation is suspected to play a role in the genesis of epileptic processes. In the present study we quantified the number of glutamate+ve neurons in the mediodorsal thalamic nucleus (MD) of genetic absence epilepsy rats from Strasbourg (GAERS) and compared these with values for normal Wistar rats. The MD thalamic nucleus was removed from each animal and the glutamatergic neurons were labelled using light-microscopy glutamate immunohistochemistry. The disector method was used to quantify the glutamate+ve neurons in the MD thalamic nucleus of GAERS and Wistar rats. The data were statistically analyzed. In the Wistar animals glutamate+ve neurons formed 89% and in GAERS 92.3% of the total neurons in 1000μm3 of MD thalamic nucleus. In GAERS glutamate+ve neurons showed statistically significant increase in the MD thalamic nucleus compared to Wistar animals. In Wistar animals the glutamate-ve neurons formed 11% and in GAERS 7.7% of the total neurons in 1000μm3 of MD thalamic. No significant difference was observed in glutamate-ve neurons between the two strains. The average diameter of glutamate+ve neurons showed no significance, while glutamate-ve neurons were significant between the two strains. The...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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The objective of the study was to identify the relationship between subcortical gray matter (GM) volumes and juvenile myoclonic epilepsy (JME).MethodsWe analyzed the brain magnetic resonance imaging (MRI) scans that were performed during the time of the diagnosis of epilepsy by using voxel-based morphometry (VBM) method. The volumetric three-dimensional sequence was used for structural investigation. The volumes of the thalamus, caudate nucleus, pallidum, and putamen were measured in both hemispheres of patients with JME, patients with generalized tonic–clonic seizures alone (GTCS) (as a disease control group) and he...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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