Precision Molecular Imaging of Osteoarthritis: 18F-FDG PET/MRI of Degenerative Disease in an In Vivo Canine Model

Conclusions The higher 18F-FDG SUVmax in the ACLT knees compared with the control knees reflects higher metabolic changes in the injured knees over time. Higher SUVmax at 3 weeks reflects higher metabolic activity due to joint inflammation, indicating post-ACLT acute stage. The metabolic activity reported in the control knees may be due to gait alterations and joint unloading created with the ACLT. FDG uptake of the knee in the in vivo ACLT canine model using PET/CT and MRI co-registration demonstrated to be highly sensitive in the detection of metabolic alterations in different structures comprising the knee joint. PET co-registration with the MR permits more accurate spatial resolution evaluation and region of interest delineation for the soft tissue structures in the knee joint. Multimodal PET/MRI imaging may also be beneficial for monitoring drug delivery and outcomes. FDG uptake has the potential to be a biomarker for diagnosis of early OA.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: SPECIAL MTA: Dosimetry Posters Source Type: research