Peripheral vasoconstriction induced by β‐adrenoceptor blockers: a systematic review and a network meta‐analysis

ConclusionOur results suggest that β‐adrenoceptor blockers have variable propensity to enhance peripheral vasoconstriction and that it is not related to preferential binding to β1‐adrenoceptors. These findings challenge FDA and European recommendations regarding precautions and contra‐indications of use of β‐adrenoceptor blockers and suggest that β‐adrenoceptor blockers with intrinsic sympathomimetic activity could be safely used in patients with peripheral vascular disease.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Meta ‐Analysis Source Type: research