Three new sesquiterpene lactone dimers from Carpesium faberi

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Xi-ke Xu, Ji Ye, Li-ping Chen, Wei-dong Zhang, Yong-xun Yang, Hui-liang Li Three new 2,4-linked sesquiterpene lactone dimers (SLDs), faberidilactones F-H (1–3), have been isolated from Carpesium faberi. Unlike 1 and 2, 3 was a modified Diels-Alder adduct, characteristic by a 1′-OH and a Δ5′(6′) double bond. Furthermore, the relative configuration of 1′-OH in 3 was assigned as β-configuration by comparison the experimental NOESY data with those of its two possible epimers. The exo/endo stereochemistry of 1–3 was determined by the spectrographic features of 2,4-linked SLDs that we discovered in our previous works. Compounds 1 and 2 showed potent cytotoxicity against human leukemia (CCRF-CEM) cells with IC50 value of 5.62 and 3.74μM, respectively. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
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