Pemetrexed-Induced Nephrogenic Diabetes Insipidus

We present a case of nephrogenic diabetes insipidus without severely reduced kidney function and propose a mechanism for the isolated finding. Severe hypernatremia can lead to encephalopathy and osmotic demyelination, and our report highlights the importance of careful monitoring of electrolytes and kidney function in patients with lung cancer receiving pemetrexed.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research