Childhood abuse is associated with worse survival following lung transplantation - Kennedy CC, Zubair A, Clark MM, Jowsey-Gregoire S.
CONTEXT: Psychosocial factors can impact lung transplant outcomes. However, it is currently unknown whether abuse survivorship influences lung transplant survival. OBJECTIVE: To characterize the abuse history of adult lung transplant patients and d...
AbstractMucopolysaccharidoses (MPS) are a group of hereditary disorders caused by lysosomal storage of glycosaminoglycans (GAGs) and characterized by a wide variability of phenotypes from severe fetal-neonatal forms to attenuated diseases diagnosed in adult individuals. The clinical picture generally worsens with age due to progressive storage involving mucosal tissue, upper airways and lungs, bones and joints, central and peripheral nervous system, heart, liver, eye, and ear. Cardiac storage of GAGs involves valves, heart muscle, and vessels (particularly the coronary arteries), and can be specific in relation to differen...
CRITICAL CARE CLINICS
Lung transplantation is the gold standard for treating patients with end-stage lung disease. Such patients can present with severe illness on the waitlist and may deteriorate before a lung donor is available. Bridging strategies with extracorporeal membrane oxygenation (ECMO) are valuable for getting patients to transplant and provide a chance at survival. The current article describes the indications, contraindications, and techniques involved in bridging to lung transplantation with ECMO.
Long-term outcomes after lung transplantation (LTx) remain inferior to other solid organs such as heart transplantation. This is largely a result of a high prevalence of chronic lung allograft dysfunction (CLAD), affecting approximately 50% of transplanted patients at 5 years post-transplant.1 Although Bronchiolitis Obliterans Syndrome (BOS) is the major clinical phenotype of CLAD (occurring in 70% of CLAD patients), Restrictive Allograft Syndrome (RAS), the other CLAD phenotype (30%), has a worse survival following diagnosis.
Since the Fontan operation was first performed in 1968, the procedure has been refined to afford the best long-term outcome for patients with single ventricle physiology, with recent studies showing 70% freedom from Fontan failure including the need for cardiac transplant at 20 years.1 Despite these improvements, the inherent physiology of the Fontan palliation with passive venous blood flow from the body to the pulmonary arteries can result in a variety of complications related to chronic venous congestion and low cardiac output.
Elevated blood pressure (BP) has been linked to adverse events during left ventricular assist device support. We aimed to investigate the association between outpatient BP and stroke or suspected pump thrombosis among HeartMate II (HMII) recipients.
The objective of the present study was to develop a method to improve the retention of hiPSCs in the myocardium for cardiac therapy.