Citalopram pulse-loading for treatment-resitant obsessive-compulsive disorder: preliminary data from an open-label trial

Treatment resistance is a frequent situation in Obsessive Compulsive Disorder (OCD), occurring in 40–60% of patients. However, in the current literature there are only a few evidence-based options for treatment resistant patients. Pulse-loading treatment consists in a rapid titration of the pharmacological agent in the first days of treatment. A few studies suggested that this kind of titration with intravenous clomipramine could result in a greater and faster response than with a standard titration in OCD resistant patients (Koran et al., 2006; Grassi et al., 2013).
Source: European Neuropsychopharmacology - Category: Psychiatry & Psychology Authors: Source Type: research