Epigenetic modifications: mechanisms of disease and biomarkers of food allergy.

Epigenetic modifications: mechanisms of disease and biomarkers of food allergy. Curr Opin Immunol. 2016 May 21;42:9-15 Authors: Martino DJ, Saffery R, Allen KJ, Prescott SL Abstract The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. As epigenetic modifications, including DNA methylation, are at the interface between the environment and the genome, they may be ideal biomarkers of modifiable disease pathways. High-throughput methylation profiling of immune cell subtypes or whole blood from patients allows the identification of disease specific epigenetic variants. If faithfully tracking with disease parameters, these 'signatures' may have clinical applications as biomarkers of disease or therapeutic response. Development of such tools will depend on a number of factors, including determining the most appropriate experimental approach, analysis methodology, patient groups, and informative target cells/tissues. Here we discuss these potential applications and their implications for food allergy practise. PMID: 27218660 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research

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Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research
Purpose of review Food allergy remains a disease of global public health significance well known to impact social, emotional, and financial well being. This review aims to summarize the existing literature focused on the direct, indirect, and intangible costs of food allergy at the household and healthcare system levels, and begin to discuss how emerging treatment and prevention strategies may be leveraged to comprehensively care for the food allergic population with the efficient use of health resources. Recent findings Food allergy imposes significant costs to multiple stakeholders and largely impact families at the...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research
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Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research
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Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research
Parents of children with food allergies should acknowledge their kids'anxiety, as well as their own, a group of allergy experts advises.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news
(Reuters Health) - Parents of children with food allergies should acknowledge their kids' anxiety, as well as their own, a group of allergy experts advises.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Individuals with life-threatening food allergy (FA) often experience elevated anxiety as they avoid accidental exposure to allergens, modify daily routines, and undergo treatments: In sum, quality of life can be adversely impacted.1-5 Allergists providing diagnostic and treatment services for these patients frequently hear about these psychosocial struggles, however, little is known about the interaction of the medical and psychosocial needs of FA children and families.3 Therefore, this study was conducted to explore the challenges children and families encounter during their FA journey, and factors associated with better ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Conclusion: FHRs to seafish in AD patients are associated with persistent eczematic lesions and with the higher occurrence of sensitization to fungi and reactions to celery. The occurrence of bronchial asthma, rhinitis, positive family history, and onset of AD under 5 years of age is higher in patients with reactions to seafish, but the difference is not statistically significant.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
We greatly appreciate the published findings by Perkin et  al1 and agree these data should further inform infant feeding guidelines. However, to best interpret these outcomes with respect to food allergy prevention recommendations, we find it helpful to review study definitions and study design nuances of both the Learning Early about Peanut (LEAP) and En quiring About Tolerance (EAT) trials.2,3 We believe the conclusion that low-risk infants do not benefit from allergenic food introduction is overstated.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
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Source: Health Communication - Category: Health Management Authors: Source Type: research
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