The Impact of Peripheral Arterial Disease: A Proposal for a New Classification

Publication date: Available online 24 May 2016 Source:Cirugía Española (English Edition) Author(s): Fernando Vaquero Morillo Classically, intermittent claudication, an intermediate stage in peripheral arterial disease, has been considered as a benign condition when considering only the muscular pain on walking. In this paper our aim is to attract attention about the effects linked to ischaemic pain and the oxidative injury resulting from episodes of ischaemia/reperfusion. Throughout this process alterations in calcium homeostasis as well as uncontrolled generation of reactive oxygen species, in association with the mitochondrial dysfunction and inflammatory phenomena, could lead to accelerate atherosclerosis, with an increased cardiovascular risk stated by means of a reduced ankle-brachial index. Taking this idea into account we propose a possible new classification for the management of the peripheral arterial disease, combining the Fontaine and Rutherford classifications and thinking about the described systemic effects in order to change the traditional management of peripheral arterial disease.
Source: Cirugia Espanola - Category: Surgery Source Type: research

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Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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