Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition

Conclusion Our findings establish that S-zofenopril improves vascular function by potentiating the H2S pathway in a model of spontaneous hypertension. This novel mechanism, unrelated to ACE inhibition and based on H2S release, could explain the beneficial effects of sulfhydrylated ACE inhibitors reported in the clinical literature.

http://cardiovascres.oxfordjournals.org/cgi/content/short/102/1/138?rss=1

Source: Cardiovascular Research - March 18, 2014 Category: Cardiology Authors: Bucci, M., Vellecco, V., Cantalupo, A., Brancaleone, V., Zhou, Z., Evangelista, S., Calderone, V., Papapetropoulos, A., Cirino, G. Tags: Vascular biology Source Type: research