Effect of Seizures on the Developing Brain and Cognition
Epilepsy is a complex disorder, which involves much more than seizures, encompassing a range of associated comorbid health conditions that can have significant health and quality-of-life implications. Of these comorbidities, cognitive impairment is one of the most common and distressing aspects of epilepsy. Clinical studies have demonstrated that refractory seizures, resistant to antiepileptic drugs, occurring early in life have significant adverse effects on cognitive function. Much of what has been learned about the neurobiological underpinnings of cognitive impairment following early-life seizures has come from animal models.
Publication date: Available online 1 April 2020Source: Brain StimulationAuthor(s): Jing-Bo Gao, Min Bao
Authors: Mégevand P, Seeck M Abstract Introduction: Electric source imaging (ESI) refers to the estimation of the cerebral sources of electric signals recorded at the head surface using electroencephalography (EEG). Thanks to the availability of EEG systems with high numbers of electrodes and to progress in software to analyze the signals they collect, ESI can be applied to epilepsy-related pathological EEG signals like interictal spikes and seizures.Areas covered: In this narrative review, we discuss selected original research articles on the use of ESI in epilepsy patients considered for surgery. Epilepsy-...
Conclusions: RC is reported to be effective in treating a variety of diseases. Current pharmacological studies on RC mainly focus on the nervous, circulatory, digestive, and endocrine systems, as well as drug withdrawal. Although experimental data support the beneficial effects of this drug, its physiological activity remains a concern. Nonetheless, this review provides a foundation for future research. PMID: 32223481 [PubMed - in process]
Pre-eclampsia was associated with a slightly increased risk of epilepsy, autism and other neurodevelopmental problems in offspring.
Publication date: Available online 1 April 2020Source: Epilepsy &BehaviorAuthor(s): Alain Braillon
In this study we report a subtype of ES which is accompanied by two consecutive muscular contractions. This subtype has not been previously classified and may emerge via a complex epileptic network. We named these seizures “epileptic spasms with biphasic muscular contractions (ES-BMC)” and analyzed the association between them and CC outcomes. We enrolled 17 patients with ES who underwent CC before 20 years of age, and analyzed the records of long-term video-electroencephalogram (EEG) recordings. The outcomes of CC were ES-free (Engel's classification I) in 7 and residual ES (II to IV) in 10 patients. We statis...
OBJECTIVE: Posttraumatic epilepsy (PTE) is a well-described complication of traumatic brain injury (TBI). The majority of the available data regarding PTE stem from the adult population. Our aim was to identify the clinical and radiological risk factors as...
(Novela Neurotech) A collaboration between Novela Neurotech and NeuroTechX launches a month-long challenge with cash prize for everyone working from home. The challenge aims to harness a new generation of AI and online big data resources to develop better seizure prediction algorithms using scalp EEG signals. Winning solutions will be made available online and open-sourced to encourage further improvements.
We report a 7-year-old boy with this syndrome whose refractory and behavioral abnormalities have been remarkably improved by treatment with LCM.
A variety of neuropeptides play important roles as neurotransmitters or neurotransmitter modifiers in the brain, and may be involved in the incidence and development of epilepsy. In recent years, the following neuropeptides: galanin (GAL), neuropeptide Y (NPY), neuropeptide substance P (SP), cholecystokinin (CCK), as well as wake-promoting neuropeptide (ORE) have been discovered to be closely associated with epilepsy. Vagus nerve stimulation (VNS) is an effective therapy for patients with drug-resistant epilepsy .