Pediatric SUDEP: What Have we Learned from Animal and Human Studies and Can we Prevent it?
Several factors, such as epilepsy syndrome, poor compliance and increased seizure frequency increase the risks of sudden unexpected death in epilepsy (SUDEP). Animal models have revealed that the mechanisms of SUDEP involve initially a primary event, often a seizure of sufficient type and severity, which occurs in a brain which is vulnerable to SUDEP due to either genetic or antecedent factors. This primary event initiates a cascade of secondary events starting, as some models indicate, with cortical spreading depolarization which propagates to the brainstem where it results in autonomic dysfunction.
The objective of this study was to develop an in-situ gel containing lorazepam (LZM) loaded nanostructured lipid carriers (NLCs) for direct nose-to-brain delivery in order to increase drug therapeutic efficacy in the treatment of epilepsy. Accordingly, LZM loaded NLCs were formulated using emulsification solvent diffusion and evaporation method; then the effects of the formulation variables on different physicochemical characteristics of NLCs were investigated. Thermosensitive in-situ gels containing LZM-NLCs were prepared using a combination of chitosan and β-glycerol phosphate (β-GP). The anticonvulsant efficac...
Charlotte Figi, a child with a catastrophic type of epilepsy who went on to inspire a CBD movement, has passed away at age 13. CNN's Dr. Sanjay Gupta reflects on her life.
Publication date: June 2020Source: Epilepsy &Behavior, Volume 107Author(s): María Puig-Molto, Emilio Pol-Yanguas, Lidia Segarra, Blanca Lumbreras
Authors: Li R, He M, Wu B, Zhang P, Zhang Q, Chen Y Abstract α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as a causal factor in patients with intractable epilepsy results in neurotransmission failure. Brain-specific serine/threonine-protein kinase 1 (SAD-B), a serine-threonine kinase specifically expressed in the brain, has been shown to regulate AMPA receptor-m...
Publication date: Available online 8 April 2020Source: Psychiatric Clinics of North AmericaAuthor(s): Benjamin Tolchin, Lawrence J. Hirsch, William Curt LaFrance
Publication date: June 2020Source: Epilepsy &Behavior, Volume 107Author(s): Andreu Massot-Tarrús, Kevin P. White, Seyed Reza Mousavi, Susan Hayman-Abello, Brent Hayman-Abello, Seyed M. Mirsattari
In conclusion; Beta-Propeller Protein Associated Neurodegeneration should be considered as an option in the diagnosis of female patients with clinical findings of epilepsy, growth retardation and autism, with unspecified etiology. PMID: 32253879 [PubMed - in process]
In this report, we present a 5-year-old boy who had dysmorphic features, hypotonia, developmental and mental delay, epileptic spasms, recurrent apnea and respiratory failure that led to the diagnosis of an unreported mutation of a rare form of CDG-Ix. This mutation in the STT3B gene affects the catalytic subunit of the oligosaccharyltransferase and the recipient substrate properties, which in part have the same functions in N-glycosylation. A novel homozygous mutation in the STT3B presence of c.38C> G that encodes p.S13W (p.Ser13Trp) was detected with next generation sequencing. The CDG clinical spectrum can be unusual,...
In conclusion; Beta-Propeller Protein Associated Neurodegeneration should be considered as an option in the diagnosis of female patients with clinical findings of epilepsy, growth retardation and autism, with unspecified etiology. PMID: 32253874 [PubMed - in process]
A Colorado girl with a rare form of epilepsy whose recovery inspired the name of a medical marijuana oil that drew families to the state has died