Efficacy and Feasibility of Intensity-Modulated Radiation Therapy for Prostate Cancer in Renal Transplant Recipients

The objective of the study was to analyze the efficacy and feasibility of intensity-modulated radiation therapy (IMRT) for prostate cancer in renal transplant recipients (RTRs).
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Tags: 14th Congress of the Asian Society of Transplantation Source Type: research

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Metastasis of prostate cancer (PCa) to renal pelvis is extremely rare. A 64-year-old man was hospitalized for increased prostate specific antigen (PSA) after radical prostatectomy. 68Ga-PSMA-11 PET/CT showed hydronephrosis caused by a mass in the left renal pelvis without significant uptake of PSMA tracer. The histopathology indicated metastatic PCa with a Gleason score of 5+5 but negative for prostate specific membrane antigen (PSMA) following nephroureterectomy. Although metastasis to renal pelvis is rare, the occurrence possibility could not be ignored when with hydronephrosis is found in prostate cancer patients.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Forced diuresis may improve readability of 2-(3-(1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL) PET/computed tomography (CT) by reducing focal ureteral activity. A total of 40 patients received furosemide simultaneously with 18F-DCFPyL (cohort 1) and 40 patients received furosemide 85 min after 18F-DCFPyL administration (cohort 2). The frequency of occurrence of activity depositions in ureters and halo artefacts near the kidneys and bladder was measured, as well as intensity of 18F-DCFPyL uptake in kidneys and bladder. At 120 min after injection of 18F-D...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: TECHNICAL NOTE Source Type: research
262Objectives: In order to standardize interpretation of PSMA PET, a molecular imaging PSMA scoring system (miPSMA) was recently introduced, considering degree of radiotracer uptake, in relation to reference structures [1]. To allow accurate quantification of radiotracer uptake on PET, several corrections are needed including partial volume effect (PVE) [2]. PVE originates from the finite spatial resolution of the PET and causes underestimation of the measured activity concentration especially for lesions at or below the resolution of the scanner [3]. Clinically, this may become relevant when assessing radiotracer uptake i...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiac and Cancer Imaging (Data Management, PIDS) Source Type: research
ConclusionsThree-dimensional printing shows revolutionary potentials for patient counseling, pre- and intraoperative surgical planning, and education in urology. Together with the “patient-tailored” presurgical planning, it puts the basis for 3D-bioprinting technology. Although costs and “production times” remain the major concerns, this kind of technology may represent a step forward to meet patients’ and surgeons’ expectations.Patient summaryThree-dimensional printing has been used for several purposes to help the surgeon better understand anatomy, sharpen his/her skills, and guide the...
Source: European Urology - Category: Urology & Nephrology Source Type: research
AbstractIntroductionSilodosin determines smooth muscle relaxation in bladder and prostate tissues, increases bladder blood flow in conditions of chronic bladder ischemia and regulates the activity of transcriptional factors responsible for stromal growth and prostate hyperplasia. Phase III trials have already demonstrated the efficacy and safety of silodosin in the treatment of patients bothered by lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).ObjectiveWe aimed to describe the rationality for the use of silodosin and to summarize the current literature on the use of Silodosin for the t...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Abstract A 72-year-old Japanese man presented to the hospital with complaints of gross hematuria. Contrast enhanced computed tomography revealed a broad-based, approximately 3-cm bladder tumor near the right ureteral orifice and a 5-cm mass located between the prostate and rectum. The patient underwent transurethral resection of the bladder tumor and a transrectal biopsy of the lesion. Histological examination of the specimens suggested that the patient had a muscle invasive adenocarcinoma from TURBT and a rectal gastrointestinal stromal tumor in TRUS biopsy. Patient underwent total pelvic exenteration and ileal a...
Source: Urology Journal - Category: Urology & Nephrology Authors: Tags: Urol J Source Type: research
Abstract If prostate cancer recurs after primary treatment, deprivation therapy with LHRH analogues or antagonists is the treatment of choice in men with metastatic prostate cancer. However, this treatment only achieves palliative results. Median time to progression ranges between 11 and 78 months. After the introduction of Docetaxel as a first-line treatment in castration-resistant prostate cancer (CRPCA) and cabazitaxel as a second-line chemotherapy, several new drugs containing abiraterone, enzalutamide, radium 223 and sipuleucel-T have become available, which can lead to complete or partial remissions in metas...
Source: Aktuelle Urologie - Category: Urology & Nephrology Authors: Tags: Aktuelle Urol Source Type: research
We report an unprecedent, exuberant and persistent inflammatory reaction following injection of that substance. Patient: a 17 years-old patient with vesico-ureteral reflux and complete pyelocaliceal right duplication was submitted to treatment with polyacrylate-polyalcohol copolymer (STING technique). In the seventh day of post-operatory, she presented intense dysuria and hypogastric pain, without laboratory exams alterations; a symptomatic treatment was started. After two months, the symptoms persisted and an ultrasound detected thickening of bladder wall close to the uretero-vesical junction. After that exam, a cystostop...
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conclusion: The impacts of cancer in Taiwan are very large. Future studies must consider both quality of life and the entire impact from societal perspectives. PMID: 29872347 [PubMed]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Epidemiol Source Type: research
CONCLUSIONS: We conclude palliative TURP remains an important surgical option to relieve bladder outlet obstruction in patients with locally advanced prostate cancer, but is ineffective to relieve ureteral obstruction. PMID: 29880461 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
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