Cardiac sarcoidosis: Diagnosis and therapeutic challenges.

[Cardiac sarcoidosis: Diagnosis and therapeutic challenges]. Rev Med Interne. 2016 May 19; Authors: Cohen Aubart F, Nunes H, Mathian A, Haroche J, Hié M, Le-Thi Huong Boutin D, Cluzel P, Soussan M, Waintraub X, Fouret P, Valeyre D, Amoura Z Abstract Sarcoidosis is a granulomatous disorder of unknown cause characterized by non-caseating granuloma in young adults. Cardiac involvement is rare and range from 2 to 75% depending on diagnostic criteria. Cardiac involvement in sarcoidosis may be asymptomatic or may manifest as rhythm/conduction troubles or congestive heart failure. The diagnosis and treatment of cardiac sarcoidosis may be challenging. However, advances have come in recent years from the use of cardiac MRI and (18)FDG-TEP scanner, as well as from the stratification of the risk of ventricular tachycardia/fibrillation. Due to the rarity of the disease, there is no reliable prospective large study to guide therapeutic strategy for cardiac sarcoidosis. Corticosteroids are probably efficacious, in particular in case of atrio-ventricular block or moderate heart failure. Immunosuppressive drugs have not been largely studied but methotrexate could be helpful. In refractory forms, TNF-α antagonists have been used with success. PMID: 27211064 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research

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