Oxandrolone, propranolol combo increases growth in severely burned children

CHICAGO – Combination therapy with oxandrolone and propranolol can attenuate burn-induced growth arrest and increase growth rate in severely burned children, according to findings from a prospective, randomized clinical trial. Of 612 children with burns over at least 30% of their total body...
Source: Skin and Allergy News - Category: Dermatology Source Type: news

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Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are intrinsic to the B cells.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Biallelic loss-of-function mutations in serine-threonine kinase 4 (STK4), also known as mammalian sterile 20-like 1 (MST1), are associated with a combined immunodeficiency characterized by recurrent bacterial, fungal, and viral infections.1-6 Most patients have intermittent neutropenia, T and B lymphopenia, and, paradoxically, specific antibody defects despite the reported presence of increased levels of serum IgG, IgA, and IgE antibodies and antibody-mediated autoimmune cytopenias.1-6
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research
“PTSD is a whole-body tragedy, an integral human event of enormous proportions with massive repercussions.” ― Susan Pease Banitt This question came up in conversation when I was speaking with someone who has experienced severe panic attacks to the point of calling them “debilitating”, requiring inpatient care.  As they were sharing about the ordeal, they told me that when they contemplate the time spent seeking treatment and the aftermath, it ramped up both the anxiety and PTSD symptoms. Even as a career therapist with decades of experience treating people with stand-alone anxiety, ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Personal Psychotherapy PTSD Trauma Aromatherapy Breathing Exercise PTSD trigger Relaxation Self Care Source Type: blogs
Prescribed burns are one method to help reduce and contain wildfires. We investigated whether the health impacts of a prescribed burn are different from that of a wildfire of the same size.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Glaukos is probably at the top of its game when it comes down to maintaining a presence in the micro-invasive glaucoma surgery (MIGS) market. The San Clemente, CA-based company reaffirmed its laser-like focus on the market during a presentation at the 37th annual J.P. Morgan Healthcare Conference earlier on Wednesday. Glaukos’ CEO Thomas Burns began his presentation speaking on the strengths of the firm and its goals going forward. “Our mission is aspirational,” Burns said. “As a company we are seeking to transform glaucoma therapy, and in doing so we ...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
(NIH/National Institute of Allergy and Infectious Diseases) A new commentary from National Institutes of Health scientists asserts that engaging men in HIV prevention and care is essential to the goal of ending the HIV pandemic. The article by Adeola Adeyeye, M.D., M.P.A., and David Burns, M.D., M.P.H., of the National Institute of Allergy and Infectious Diseases (NIAID) and Michael Stirratt, Ph.D., of the National Institute of Mental Health (NIMH) also discusses potential solutions.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
ConclusionIFI occurred in 9.6% of patients treated with HMA, but was observed in 20.4% of those who were neutropenic on C1D1 of HMA. Another potential risk factor identified was t-MDS versus de novo MDS. Prospective evaluation of mold-active antifungal prophylaxis in patients with MDS or AML who are neutropenic at the start of HMA therapy is warranted.DisclosuresFrey: Novartis: Consultancy; Servier Consultancy: Consultancy. Perl: Arog: Consultancy; NewLink Genetics: Membership on an entity's Board of Directors or advisory committees; Pfizer: Membership on an entity's Board of Directors or advisory committees; Astellas: Con...
Source: Blood - Category: Hematology Authors: Tags: 637. Myelodysplastic Syndromes-Clinical Studies Source Type: research
Abstract Bradykinin is produced in response to inflammation, trauma, burns, shock, allergy and some cardiovascular diseases. Actions of this peptide are mediated through two different G-protein coupled receptors, named B1 and B2 that have different pharmacological characteristics. The former is up-regulated during inflammation episodes or tissue trauma whereas, the latter is constitutively expressed in a variety of cell types. In a previous work we have characterized the molecular features that explain the observed structure-activity results for both receptors by means of molecular modeling studies, using diverse ...
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Tags: Bioorg Med Chem Lett Source Type: research
It ’s 1970 and 10-month-old Maurice Elias lay in a hospital bed in the pediatric intensive care unit dangerously malnourished, at just 14 pounds, and with a severe infection in his mouth. The antibiotics that doctors at UCLA had been using to treat Maurice, who had been born without a functional immu ne system, were no longer working.The only way Maurice was going to survive was a bone marrow transplant.“If we couldn't find a way to give Maurice a working immune system, he was going to die. And the only way to do so was with a risky transplant that could be fatal, too,” said Dr. Richard Stiehm, the UCLA d...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Publication date: Available online 23 July 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Elizabeth Rivers, Austen Worth, Adrian J. Thrasher, Siobhan O. Burns
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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