Spreading Depression in Primary and Secondary Headache Disorders
Abstract Purpose of Review Spreading depression (SD) is a wave of simultaneous and near-complete depolarization of virtually all cells in brain tissue associated with a transient “depression” of all spontaneous or evoked electrical activity in the brain. SD is widely accepted as the pathophysiological event underlying migraine aura and may play a role in headache pathogenesis in secondary headache disorders such as ischemic stroke, subarachnoid or intracerebral hemorrhage, traumatic brain injury, and epilepsy. Here, we provide an overview of the pathogenic mechanisms and propose plausible hypotheses on the involvement of SD in primary and secondary headache disorders. Recent Findings SD can activate downstream trigeminovascular nociceptive pathways to explain the cephalgia in migraine, and possibly in secondary headache disorders as well. In healthy, well-nourished tissue (such as migraine), the intense transmembrane ionic shifts, the cell swelling, and the metabolic and hemodynamic responses associated with SD do not cause tissue injury; however, when SD occurs in metabolically compromised tissue (e.g., in ischemic stroke, intracranial hemorrhage, or traumatic brain injury), it can lead to irreversible depolarization, injury, and neuronal death. Recent non-invasive technologies to detect SDs in human brain injury may aid in the investigation of SD in headache disorders in which invasive ...
Conclusion: By influencing a certain patient population throughout the organization, population-focused CNSs are in a unique role to lead an interprofessional team or serve as an expert consultant in pursuing DSC certification from The Joint Commission.
Conclusions: Implementation of an adapted aspiration risk assessment screening tool to document risk of hospital-acquired aspiration pneumonia and aspiration precautions protocol was associated with a decrease in aspiration pneumonia rates.
More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?
ConclusionThough the complication rate was found to be higher than most of the other studies, they were minor which resolved without any intervention. The cases with complications were clustered at the beginning of the series which suggests the steep learning curve and the importance of surgeons ’ experience and skill involved in this procedure.
ConclusionThe ease of mobilization, superior blood supply and minimal donor site morbidity make it an ideal flap and a reliable alternative when other techniques fail.
In this issue, Tang et al.  from Taiwan report on an increasingly important issue in thoracic medicine and surgery, the natural history of small, asymptomatic lung nodules. The widespread use, over the last couple of decades, of increasingly sensitive computed tomography (CT) scans with reducing radiation dose has resulted in the recognition of a significant population of otherwise healthy patients who have a lung nodule of undefined nature. In most cases, this lung nodule has been detected at the time of a CT scan for a completely different issue —atypical chest pain, back pain, shoulder pain, and often for inves...
CONCLUSION: In patients with isolated LMI, we postulate that disruption of the descending pathway from the pontine micturition centre to the sacral spinal cord at the level of the lateral tegmentum results in urinary retention. PMID: 31607099 [PubMed]
Authors: Wrigley J, Carden V, von Isenburg M Abstract This project characterized current research and collaboration patterns in pain research at one institution after researchers working on a grant application approached the library to better understand current institutional research and publishing about that topic. To address this question, library staff developed a collaborative, multi-tool process for bibliometric analysis and network visualization. The primary data source used was a preexisting, curated EndNote library of institutional publications. This EndNote library was searched using keywords relevant to t...
This study offers preliminary evidence that immune responsivity to stress induction could serve as a mechanism of treatment for mood disorders in youth, indicating a potential marker for more personalized model of healthcare.
Authors: Altaner C, Altanerova U, Jakubechova J PMID: 31608134 [PubMed]