Oxidative stress mediates dibutyl phthalateinduced anxiety-like behavior in Kunming mice

In this study, we found that neurobehavioral changes induced by DBP may be mediated by oxidative damage in the mouse brain, and that the co-administration of Mangiferin (MAG, 50mg/kg/day) may protect the brain against oxidative damage caused by DBP exposure. The results of ethological analysis (elevated plus maze test and open-field test), histopathological examination of the brain, and assessments of oxidative stress (OS) in the mouse brain showed that there is a link between oxidative stress and anxiety-like behavior produced by DBP at higher doses (25 or 125mg/kg/day). Biomarkers of oxidative stress encompass reactive oxygen species (ROS), glutathione (GSH), malondialdehyde (MDA) and DPC coefficients (DPC). MAG (50mg/kg/day),administered as an antioxidant,can attenuatetheanxiety-like behavior of the tested mice. Graphical abstract
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research