Atopic dermatitis and filaggrin.

Atopic dermatitis and filaggrin. Curr Opin Immunol. 2016 May 17;42:1-8 Authors: Cabanillas B, Novak N Abstract Filaggrin has a key structural and functional role in the epidermis with important impact on the homeostasis of the skin. Inherited or acquired filaggrin deficiency has been described to essentially contribute to the pathogenesis of atopic dermatitis (AD), one of the most frequent chronic eczematous skin diseases in child-hood and adult-hood. Increasing knowledge has been gained during the last years about direct and indirect consequences of filaggrin deficiency. Furthermore, with the help of novel murine and human experimental models important steps forward have been made towards the characterization of filaggrin structure and function. Future approaches aimed at restoration of filaggrin expression may open novel mechanism-based therapies for AD. PMID: 27206013 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research

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Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Authors: Howell AN, Ghamrawi RI, Strowd LC, Feldman SR Abstract Introduction: The prevalence of atopic dermatitis (AD) in geriatric populations of industrialized countries is currently estimated at 3-4% and continues to increase. AD is associated with significant morbidity, increased susceptibility to infection, and symptoms of pruritus and pain. Treatments may negatively affect elderly patients; thus, plans should be optimized for this population.Areas covered: This review summarizes treatment options for AD in the elderly. A systematic review of the literature was conducted using the key terms atopic dermatitis, ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
AbstractPopulation pharmacokinetic base and covariate models were developed to study functional dupilumab for regulatory submissions, using data from healthy volunteers and patients with moderate ‐to‐severe atopic dermatitis (AD) receiving intravenous or subcutaneous doses. Sixteen studies were pooled (N = 2115; 202 healthy volunteers, 1913 AD patients). The best model was a 2‐compartment model with linear and Michaelis‐Menten elimination and 3 transit compartments describing absor ption. A stepwise approach to model building, with some parameters estimated using mostly rich data and subsequently fixed, w...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
Allergic Contact Dermatitis
Source: Dermatologic Clinics - Category: Dermatology Source Type: research
Publication date: Available online 26 February 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kristin Schmidlin, Sonam Sani, David I. Bernstein, Luz Fonacier
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Purpose of review To present and discuss key design concepts for optimizing the impact of observational studies in the field of allergy and to highlight recent findings from NIAID-funded research networks. Recent findings We discuss three concepts. First, the benefit of prospective, longitudinal observational studies exemplified by recent findings on the seasonal nature of all rhinitis phenotypes in children with asthma and the protective effects of high house dust allergen content during the first year of life on the development of asthma at age 7 years. Second, the benefit of detailed (deep) phenotyping exemplified ...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research
Purpose of review Protein contact dermatitis (PCD) is a chronic eczema because of immediate hypersensitivity to protein and not related to haptens. As it has to be diagnosed by prick tests, it is probably under-recorded and under-estimated that is why it is important for dermatologists, allergists and occupational physicians to better know this peculiar contact dermatitis. Recent findings Some recent series have emphasized that PCD is mainly an occupational dermatosis, mainly observed in food handlers. Summary PCD is a chronic eczematous dermatitis, possibly exacerbated by work, suggested if associated with inflamm...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: OCCUPATIONAL DISEASE: Edited by Susan M. Tarlo and Piero Maestrelli Source Type: research
Authors: Joergensen KM, Vestergaard C, Joergensen MS, Eiken A, Malmstedt-Miller M, Schultz ANØ, Deleuran M, Zibert JR Abstract Background: Atopic dermatitis (AD) is a chronic skin condition where nonadherence often results in lack of disease control. Objective: We wanted to determine whether the combination of an electronic memory button and a supportive application (app) would affect the Quality of Life and subjective and objective severity measures among AD patients over one month following the patient's normal schedules of treatment. Methods: A randomized, investigator-blinded, prospective observa...
Source: Dermatology Research and Practice - Category: Dermatology Tags: Dermatol Res Pract Source Type: research
Conditions:   Conjunctivitis;   Atopic Dermatitis Intervention:   Drug: dupilumab Sponsors:   Regeneron Pharmaceuticals;   Sanofi Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
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