World report on fertility treatments reveals high use of intracytoplasmic sperm injection
(European Society of Human Reproduction and Embryology) The editor-in-chief of one of the world's leading reproductive medicine journals, Human Reproduction, has attacked the rising use of intracytoplasmic sperm injection (ICSI) for the treatment of infertility, following publication of the latest world report on assisted reproductive technologies; he brands it as 'ineffective and costly care.'
Condition: Infertility Interventions: Drug: prednisolone; Drug: Acetyl Salicylic acid Sponsor: Kasr El Aini Hospital Not yet recruiting
Conclusion Subfertile women with a WHO II ovulation disorder have a good prognosis on live birth, and most did so after ovulation induction with clomiphene-citrate. If first-line ovulation induction has failed ovulation induction with gonadotrophins or IVF still result in a live birth in about half of the cases.
500,000 men in the US undergo vasectomy annually. About 6% will change their mind. 2 options to conceive are vasectomy reversal (VR) or sperm retrieval (SR) with in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Often the male partner is only evaluated by a urologist and counseled and treated with a VR without an evaluation or counseling of the female, or the female is evaluated by a reproductive endocrinologist (RE) on the option of IVF/ICSI, and the male partner is referred to a urologist to perform SR for use with IVF/ICSI.
We examined the effect of microsurgical subinguinal varicocele repair (VR) on sperm DFI assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and/or sperm chromatin structure assay (SCSA) and correlated these data with pregnancy and live birth outcomes at IVF/ICSI.
Microdissection testicular sperm extraction (micro TESE) is the major surgical procedure of sperm retrieval for patients with non-obstructive azoospermia (NOA) in artificial reproductive technique (ART) with intracytoplasmic sperm injection (ICSI). At micro TESE, seminiferous tubules with larger diameter (>300 μm) are searched and picked under the operative microscope, and the tissue is sent for sperm retrieval by the embryologist. When the sperm is confirmed retrieved, and the procedure of micro TESE can then be finished.
For over a decade, no studies have compared fertility outcomes between vasectomy reversal (VR) and in vitro fertilization (IVF) with intracytoplasmic sperm injection for older couples seeking a biologic child. We sought to provide pregnancy rates from a contemporary series of VR in men with female partners 35 years and older, and to correlate the results with pregnancy rates via IVF for women 35 years and older.
Sperm deoxyribonucleic acid (DNA) fragmentation has been associated with male infertility and studies suggest that sperm DNA fragmentation can have an adverse influence on pregnancy outcomes with assisted reproduction. The aim of the present study was to examine the intracytoplasmic sperm injection (ICSI) pregnancy outcomes using testicular sperm in couples that have failed ICSI cycles using ejaculate sperm.
Sperm DNA fragmentation is a biomarker of male infertility and results in poorer IVF outcomes. The Comet assay measures the DNA damage in individual sperm enabling the degree of heterogeneity of the whole sperm population to be assessed. The aim of this study was to explore the impact of this heterogeneity, assess the diagnostic and predictive power of novel Comet parameters that quantify different damage levels in the semen sample. We also determined if quantifying the proportion of sperm with low or high DNA damage increases the predictive value of Comet test for the diagnosis of male infertility and prediction of ART live birth rates.
Condition: Infertility Intervention: Other: ICSI Sponsor: Reproductive Medicine Associates of New Jersey Recruiting