World report on fertility treatments reveals high use of intracytoplasmic sperm injection

(European Society of Human Reproduction and Embryology) The editor-in-chief of one of the world's leading reproductive medicine journals, Human Reproduction, has attacked the rising use of intracytoplasmic sperm injection (ICSI) for the treatment of infertility, following publication of the latest world report on assisted reproductive technologies; he brands it as 'ineffective and costly care.'
Source: EurekAlert! - Social and Behavioral Science - Category: Global & Universal Source Type: news

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Abstract Globozoospermia has been reported to be a rare but severe causation of male infertility, which results from the failure of acrosome biogenesis and sperm head shaping. Variants of dpy-19-like 2 (DPY19L2) are highly related to globozoospermia, but related investigations have been mainly performed in patients from Western countries. Here, we performed a screening of DPY19L2 variants in a cohort of Chinese globozoospermic patients and found that five of nine patients carried DPY19L2 deletions and the other four patients contained novel DPY19L2 point mutations, as revealed by whole-exome sequencing. Patient 3 ...
Source: Asian Journal of Andrology - Category: Urology & Nephrology Authors: Tags: Asian J Androl Source Type: research
This study investigated the quality and quantity of eggs and embryos as well as the clinical pregnancy outcome in young infertile women with diminished ovarian reserve (DOR) after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). MATERIAL AND METHODS We retrospectively reviewed records of 4285 infertile women and divided them into 3 groups according to age and ovarian reserve: young women with normal ovarian reserve (n=1695), young women with DOR (n=1121), and older women with DOR (n=1469). RESULTS In young women with DOR, the proportion of high-quality embryos was significantly higher than in older women...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conditions:   Infertility;   Polycystic Ovary Syndrome Intervention:   Behavioral: Fasting Sponsor:   Cairo University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
Contributors : Sanaa Choufani ; Andrei Turinsky ; Rosanna Weksberg ; Jacquetta TraslerSeries Type : Methylation profiling by arrayOrganism : Homo sapiensChildren conceived using Assisted Reproductive Technologies (ART) have a higher incidence of growth and birth defects, attributable in part to epigenetic perturbations. Both ART and germline defects associated with parental infertility could interfere with epigenetic reprogramming events in germ cells or early embryos. Mouse models indicate that the placenta is more susceptible to the induction of epigenetic abnormalities than the embryo, and thus the placental methylome m...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research
Conclusion(s)Couples with unexplained infertility that present with unexpectedly poor IUI outcomes can be funneled into a treatment algorithm guided by the integrity of the sperm genome for higher chances of pregnancy using an alternate method of insemination.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
AbstractPurposeTo investigate the effect of sperm concentration, motility and advanced paternal age on reproductive outcomes.MethodsA retrospective analysis of 1266 intracytoplasmic sperm injection (ICSI) cycles between 2013 and 2017. The cohort was divided into four groups according to semen concentration based on the WHO criteria (2010): group A (conc.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Authors: Ashrafi M, Arabipoor A, Hemat M, Salman-Yazdi R Abstract This case-control study was designed to evaluate the impact of endometriosis and the presence of endometrioma (OMA) per se on the serum anti-Müllerian hormone (AMH) level and also to compare the in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) outcomes after therapeutic surgery in endometriosis patients, according to the localisation of endometriosis lesions. One hundred and fifty two infertile women ≤40 years with suspicious symptoms were surgically evaluated to detect the aetiology of infertility at the Royan Institut...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
AbstractMenopur® is a highly purified, urine-derived, human menopausal gonadotropin containing both follicle stimulating hormone (FSH) and luteinizing hormone (LH) activity. It is an effective option for controlled ovarian stimulation (COS) in assisted reproductive technology protocols and for ovulation induction (OI) in anovulatory infertility, and is associated with a different endocrine profile from that of recombinant (r) FSH in these settings (in terms of serum levels of FSH, androgens and/or estradiol). When used for COS in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), Men...
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
Condition:   Infertility Intervention:   Diagnostic Test: Transvaginal US with Doppler study Sponsors:   Aljazeera Hospital;   Kasr El Aini Hospital;   National research centre Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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