New Insights into Flavivirus Pathogenesis and Immunity: Yes, that Includes Zika Virus.

Dr. Michael Diamond received a B.A. degree in political science at Columbia University before pursuing medical and graduate training at Harvard School of Medicine. As a graduate student, he investigated the regulation of the integrin Mac-1 (CD11b/CD18) in the laboratory of Dr. Timothy Springer. He did a residency and a clinical fellowship in infectious diseases at the University of California, San Francisco, and most of his post-doctoral training in the laboratory of Dr. Eva Harris at the University of California, Berkeley. He was recruited to Washington University in St. Louis as an Assistant Professor in 2001 and is now a full Professor with tenure. He is the co-director of the Midwest Regional Center for Excellence in Biodefense and Emerging Infectious Diseases Research and Head of the Division of Infectious Diseases and Vaccine Development, Center for Human Immunology and Immunotherapy Programs. Dr. Diamond leads an extremely productive and interdisciplinary research program focused on the pathogenesis of and immunity to viral infections. These efforts may be divided generally into i.) studies of the mechanisms of antiviral humoral immunity (West Nile virus, Dengue virus, Chikungunya virus and most recently Zika virus) and ii.) innate responses to viral infection. With respect to the former, his group has made significant contributions to understanding the humoral immunity using animal models of flavi- and alphavirus infections (e.g. Purtha, JEM, 2011) and mechanisms of a...
Source: Videocast - All Events - Category: Journals (General) Tags: Upcoming Events Source Type: video

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Mosquito bites may be a nuisance, but fortunately, in the U.S., they tend to amount to nothing more than that. Upon being bitten, most Americans experience a bit of swelling and itchiness, and nothing more. However, there are exceptions to this, including stronger allergic reactions to bites and cases of mosquito-borne illness.  Insect and arachnid bites, including ticks, account for approximately 2,000 cases of malaria and 30,000 cases of Lyme disease in the U.S. annually. In addition, millions of people worldwide die of malaria each year. It is helpful to protect yourself against insect bites, not only to avoid pesk...
Source: Conversations with Dr Greene - Category: Child Development Authors: Tags: Dr. Greene's Blog Environmental Health Insect Bites & Stings Insects & Animals Outdoor Safety Source Type: blogs
by Thiago Nunes Pereira, Fabiano Duarte Carvalho, Silvana Faria De Mendon ça, Marcele Neves Rocha, Luciano Andrade Moreira Newly emerging or re-emerging arthropod-borne viruses (arboviruses) are important causes of human morbidity and mortality worldwide. Arboviruses such as Dengue (DENV), Zika (ZIKV), Chikungunya (CHIKV), and West Nile virus (WNV) have undergone extensive geographic expansion in the tropical and sub- tropical regions of the world. In the Americas the main vectors of DENV, ZIKV, and CHIKV are mosquito species adapted to urban environments, namelyAedes aegypti andAedes albopictus, whereas the main v...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
AbstractGuillain –Barré syndrome (GBS) is an acute-onset, immune-mediated polyradiculoneuropathy, often precipitated by an antecedent infection. An association of GBS with vector-borne viral infections has been suggested, with evidence for the involvement of Zika, Dengue, Chikungunya and West Nile virus (WNV). Th is prospective case–control study was conducted to identify vector-borne viral infections in GBS. Thirteen individuals newly diagnosed as GBS were enrolled. Disease severity, prognostic factors and nerve conduction patterns were assessed. Eleven individuals with non-infectious conditions requiri...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
This report summarizes surveillance data reported to CDC for 2018 on nationally notifiable arboviruses. It excludes dengue, chikungunya, and Zika viruses because they are primarily nondomestic viruses typically acquired through travel. In 2018, 48 states and the District of Columbia (DC) reported 2,813 cases of domestic arboviral disease, including 2,647 (94%) WNV disease cases. Of the WNV disease cases, 1,658 (63%) were classified as neuroinvasive disease (e.g., meningitis, encephalitis, and acute flaccid paralysis), for a national incidence of 0.51 cases of WNV neuroinvasive disease per 100,000 population. Because arbovi...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
WEDNESDAY, July 17, 2019 -- Some mosquitoes spread diseases to humans through their bite, passing along harmful pathogens like Zika, dengue fever, West Nile virus and chikungunya. Now humans are turning the tables, infecting these dangerous...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
by Fr édéric Jourdain, Abdallah M. Samy, Afrim Hamidi, Ali Bouattour, Bülent Alten, Chafika Faraj, David Roiz, Dušan Petrić, Elisa Pérez-Ramírez, Enkeledja Velo, Filiz Günay, Golubinka Bosevska, Ibrahim Salem, Igor Pajovic, Jelena Marić, Khalil Kanani, Lusine Paronyan, Maria-Grazia Dente, Marie P icard, Marija Zgomba, M'hammed Sarih, Nabil Haddad, Oleksandr Gaidash, Roena Sukhiasvili, Silvia Declich, Taher Shaibi, Tatiana Sulesco, Zoubir Harrat, Vincent Robert BackgroundThe Mediterranean Basin is historically a hotspot for trade, transport, and migration. As a result, countrie...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Source: Association of State and Territorial Health Officials (ASTHO). Published: 5/21/2019. This 72-page document, updated from the 2005 edition, provides guidance to assist local, state, and territorial mosquito control programs in developing and maintaining effective mosquito control programs. The rapid spread of West Nile virus (WNV) and the emergence of other viruses such as dengue, chikungunya, and Zika in the United States and its territories, demonstrates the continuing need for organized mosquito control activities. Guidance is organized into four sections: Understanding the roles of government and nongovernmenta...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
María Maximina B. Moreno-Altamirano1*, Simon E. Kolstoe2 and Francisco Javier Sánchez-García1* 1Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico 2School of Health Sciences, University of Portsmouth, Portsmouth, United Kingdom Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathway in w...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Adriano Queiroz1, Isabella Fernanda Dantas Pinto2, Maricélia Lima3, Marta Giovanetti1,4, Jaqueline Goes de Jesus1, Joilson Xavier1, Fernanda Khouri Barreto5, Gisele André Baptista Canuto6, Helineide Ramos do Amaral7, Ana Maria Bispo de Filippis4, Denise Lima Mascarenhas8, Melissa Barreto Falcão8, Normeide Pedreira Santos8, Vasco Ariston de Carvalho Azevedo9, Marcos Yukio Yoshinaga2*, Sayuri Miyamoto2 and Luiz Carlos Junior Alcantara1,4,10* 1Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil 2Departamento de Bioquímica, Instituto de Quími...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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