Extracellular Expression and Antiviral Activity of a Bovine Interferon-Alpha through Codon Optimization in Pichia pastoris

In this study, we demonstrated high-level extracellular expression of opti-bIFN-α by P. pastoris. To the best of our knowledge, the opti-bIFN-α yield observed in this study is the highest to be reported to date. Our results demonstrated that the extracellular opti-bIFN-α with strong antiviral activity could be easily prepared and purified at a low cost and that it may be a potential biological therapeutic drug against bovine viral infections.
Source: Microbiological Research - Category: Infectious Diseases Source Type: research