High serum creatinine non-linearity: a renal vital sign?

High serum creatinine non-linearity: a renal vital sign? Am J Physiol Renal Physiol. 2016 May 18;:ajprenal.00025.2016 Authors: Palant CE, Chawla LS, Faselis C, Li P, Pallone TL, Kimmel PL, Amdur RL Abstract Patients with chronic kidney disease (CKD) may have non-linear serum creatinine concentration (SC) trajectories, especially as CKD progresses. Variability in SC is associated with renal failure and death. However, current methods for measuring SC variability are unsatisfactory because they blend information about SC slope and variance. We propose an improved method for defining and calculating a patient's SC slope and variance so that they are mathematically distinct, and we test these methods in a large sample of US veterans, examining the correlation of SC slope and SC non-linearity (SCNL), and the association of SCNL with time to stage-4 CKD (CKD4) and death. We found a strong correlation between SCNL and rate of CKD progression, time to CKD4 and time to death, even in patients with normal renal function. We therefore argue that SCNL may be a measure of renal auto-regulatory dysfunction that provides an early warning sign for CKD progression. PMID: 27194712 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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