Postischemic microvasculopathy and Endothelial Progenitor Cell-based therapy in ischemic AKI - update and perspectives.

Postischemic microvasculopathy and Endothelial Progenitor Cell-based therapy in ischemic AKI - update and perspectives. Am J Physiol Renal Physiol. 2016 May 18;:ajprenal.00232.2016 Authors: Patschan D, Kribben A, Müller GA Abstract Acute kidney injury (AKI) dramatically increases mortality of hospitalized patients. Incidences have been increased in recent years. The most frequent cause is transient renal hypoperfusion or ischemia which induces significant tubular cell dyfunction / damage. In addition, two further events take place: interstitial inflammation and microvasculopathy (MV). The latter evolves within minutes to hours post-ischemia and may results in permanent deterioration of the peritubular capillary network, ultimately increasing the risk for chronic kidney disease (CKD) in the long-term. In recent years, our understanding of the molecular / cellular processes responsible for acute and sustained microvasculopathy has increasingly been expanded. The methodical approaches for visualizing impaired peritubular blood-flow and increased vascular permeability have been optimized, even allowing to depict tissue abnormalities in a three-dimensional manner. In addition, endothelial dysfunction, a hallmark of MV is increasingly been recognized as inductor of both, vascular malfunction and interstitial inflammation. In this regard, so-called regulated necrosis of the endothelium could potentially play a role in postischemic inflamma...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research