Glucagon actions on the kidney revisited. Possible role in potassium homeostasis.

Glucagon actions on the kidney revisited. Possible role in potassium homeostasis. Am J Physiol Renal Physiol. 2016 May 18;:ajprenal.00560.2015 Authors: Bankir L, Bouby N, Blondeau B, Crambert G Abstract It is now recognized that the metabolic disorders observed in diabetes are not, or not only due to the lack of insulin or insulin resistance, but also to elevated glucagon secretion. Accordingly, selective glucagon receptor antagonists are now proposed as a novel strategy for the treatment of diabetes. However, besides its metabolic actions, glucagon also influences kidney function. The glucagon receptor is expressed in the thick ascending limb, distal tubule and collecting duct, and glucagon regulates the transepithelial transport of several solutes in these nephron segments. Moreover, it also influences solute transport in the proximal tubule, possibly by an indirect mechanism. This review summarizes the knowledge accumulated over the last 30 years about the influence of glucagon on the renal handling of electrolytes and urea. It also describes a possible novel role of glucagon in the short term regulation of potassium homeostasis. Several original findings suggest that pancreatic alpha-cells may express a "potassium sensor" sensitive to changes in plasma K concentration, and could respond by adapting glucagon secretion that, in turn, would regulate urinary K excretion. By their combined actions, glucagon and insulin, working in a combinatory ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Publication date: Available online 5 December 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Chen-Ti Wang, Che-Wei Chang, Yung-Chuan Lu, Hing-Chung Lam, Shu-Ju Ku, Kuo-Bin Tseng, Yu-Hsi KaoSodium-glucose cotransporter-2 (SGLT-2) inhibitors have become the best choice of second-line oral antidiabetic drugs for patients with heart or chronic kidney disease. However, it is not clear how safe this treatment is for elderly patients, especially Asians, who are known to be more insulin deficient than Caucasian individuals with a similar insulin resistance. Here, we report a case concerning an elderly patient wi...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
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Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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Source: NIH Calendar of Events - Category: American Health Source Type: events
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Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Ob/Gyn & Women ' s Health News Source Type: news
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Source: NYT Health - Category: Consumer Health News Authors: Tags: Diabetes Premature Babies Babies and Infants Pregnancy and Childbirth Source Type: news
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
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Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
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