Four new dimeric spiro-azaplilone derivatives cochliodones E-H from the entophytic fungus Chaetomium sp. M336

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Fei-Xue Yu, Yao Chen, Yin-He Yang, Pei-Ji Zhao Chaetomium sp. M336 was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation based on its special environment. To understand the secondary metabolites of strain Chaetomium sp. M336, four new dimeric spiro-azaplilone derivatives cochliodones E-H (1–4) were isolated from solid fermentation products of the fungus, which were elucidated by extensive spectroscopic analyses, including 1D- and 2D NMR, and HR-ESI–MS experiments. The antibacterial activities of compounds 1–4 against bacteria were tested in vitro. They exhibited antibacterial activities against Escherichia coli, Staphylococcus aureus, Salmonella typhimurium ATCC 6539 and Enterococcus faecalis with minimum inhibitory concentration (MIC) values of 0.78–100μg/mL. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research