Two new highly-oxygenated flavonoid glycosides from Eupatorium adenophorum Spreng

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Caifang Wang, Ru Yang, Ling Song, Baoming Ning, Canbin Ou-yang, Aocheng Cao, Lan He Two new highly-oxygenated flavonoid glycosides, gossypetin-5-O-(6″-(E)-caffeoyl)-β-d-glucoside (1) and herbacetin-5-O-(6″-(E)-caffeoyl)-β-d-glucoside (2) were isolated from the leaves of Eupatorium adenophorum Spreng. Their structures were determined by spectroscopic methods including one- and two-dimensional NMR, and HR-ESI–MS. Compounds have potent DPPH radical scavenging activity with IC50 12.0μM (1) and 22.9μM (2) (Vc as positive control, IC50 59.0μM) and inhibitory activity onproliferation of preadipocyte 3T3-L1 cells. Graphical abstract

Source: Phytochemistry Letters - May 19, 2016 Category: Chemistry Source Type: research