Gender-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions

Conclusions: Diazinon exposure perturbed the gut microbiome community structure, functional metagenome, and associated metabolic profiles in a gender-specific manner. These findings may provide novel insights regarding perturbations of the gut microbiome and its functions as a potential new mechanism contributing to diazinon neurotoxicity and, in particular, its sex-selective effects. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Gao B, Bian X, Mahbub R, Lu K. Gender-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions. Environ Health Perspect; http://dx.doi.org/10.1289/EHP202 Received: 8 July 2015 Revised: 27 October 2015 Accepted: 18 April 2016 Published: 20 May 2016 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you ne...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research